New insights into the anti- hepatoma mechanism of triple-helix β- glucan by metabolomics profiling

Liqin Cai, Shujun Zhou, Yanfeng Wang*, Xiaojuan Xu*, Lina Zhang, Zongwei Cai*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

10 Citations (Scopus)

Abstract

Natural polysaccharide as the third abundant biomacromolecule has attracted considerable attentions due to their superior anti-tumor activities. However, the anti-tumor mechanism of polysaccharides has not been completely understood. Herein, the anti-tumor effects of black fungus polysaccharide (BFP), a typical β-glucan was comprehensively investigated, and the anti-tumor mechanism was obtained from metabolomics profiling. The in vitro results demonstrate that BFP inhibited the proliferation, migration and invasion of hepatoma carcinoma cells (HCC) through inducing the cell apoptosis and arresting the cell cycle at S phase without direct cytotoxicity. The hepatoma-bearing nude mice experiments further demonstrate that BFP could significantly inhibit the growth without system toxicity in vivo. Mass spectrometry-based metabolomics unveils that BFP significantly disturbed the multiple metabolic pathways, leading to the inhibition of tumor cells proliferation by promoting DNA damage, attenuating DNA damage repair, and inhibiting DNA synthesis. This study provides new insights for pharmacological research and clinical practice of polysaccharides.

Original languageEnglish
Article number118289
JournalCarbohydrate Polymers
Volume269
Early online date2 Jun 2021
DOIs
Publication statusPublished - 1 Oct 2021

Scopus Subject Areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

User-Defined Keywords

  • Anti-hepatoma mechanism
  • Metabolic pathways
  • Metabolomics profiling
  • β-Glucan

Fingerprint

Dive into the research topics of 'New insights into the anti- hepatoma mechanism of triple-helix β- glucan by metabolomics profiling'. Together they form a unique fingerprint.

Cite this