Neutrophils may be a vehicle for viral replication and dissemination in human h5n1 avian influenza

Yingying Zhao; Min Lu; Lok Ting Lau; Jie Lu; Zifen Gao; Jinhua Liu; Albert Cheung Hoi Yu; Qi Cao; Juxiang Ye; Michael A. McNutt; Jiang Gu

doi:10.1086/593196

Neutrophils may be a vehicle for viral replication and dissemination in human h5n1 avian influenza

Yingying Zhao, Min Lu, Lok Ting Lau, Jie Lu, Zifen Gao, Jinhua Liu, Albert Cheung Hoi Yu, Qi Cao, Juxiang Ye, Michael A. McNutt, Jiang Gu^*

^*Corresponding author for this work

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Abstract

The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced realtime polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.

Original language	English
Pages (from-to)	1575-1578
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	47
Issue number	12
DOIs	https://doi.org/10.1086/593196
Publication status	Published - 15 Dec 2008

Scopus Subject Areas

Microbiology (medical)
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{29534dc37fdb4a56bd40cce7806025ab,

title = "Neutrophils may be a vehicle for viral replication and dissemination in human h5n1 avian influenza",

abstract = "The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced realtime polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.",

author = "Yingying Zhao and Min Lu and Lau, {Lok Ting} and Jie Lu and Zifen Gao and Jinhua Liu and Yu, {Albert Cheung Hoi} and Qi Cao and Juxiang Ye and McNutt, {Michael A.} and Jiang Gu",

note = "The International Collaboration Project (Project 111; B 07001) of the Ministry of Education, China; the Lifu Educational Foundation; and the National High Technology Research and Development Program of China (863 Program; 2006AA02Z452 to A.C.H.Y.) Publisher Copyright: {\textcopyright}2008 by the Infectious Diseases Society of America. All rights reserved.",

year = "2008",

month = dec,

day = "15",

doi = "10.1086/593196",

language = "English",

volume = "47",

pages = "1575--1578",

journal = "Clinical Infectious Diseases",

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TY - JOUR

T1 - Neutrophils may be a vehicle for viral replication and dissemination in human h5n1 avian influenza

AU - Zhao, Yingying

AU - Lu, Min

AU - Lau, Lok Ting

AU - Lu, Jie

AU - Gao, Zifen

AU - Liu, Jinhua

AU - Yu, Albert Cheung Hoi

AU - Cao, Qi

AU - Ye, Juxiang

AU - McNutt, Michael A.

AU - Gu, Jiang

N1 - The International Collaboration Project (Project 111; B 07001) of the Ministry of Education, China; the Lifu Educational Foundation; and the National High Technology Research and Development Program of China (863 Program; 2006AA02Z452 to A.C.H.Y.) Publisher Copyright: ©2008 by the Infectious Diseases Society of America. All rights reserved.

PY - 2008/12/15

Y1 - 2008/12/15

N2 - The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced realtime polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.

AB - The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced realtime polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.

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UR - https://academic.oup.com/cid/article/47/12/1575/332774?login=true

U2 - 10.1086/593196

DO - 10.1086/593196

M3 - Journal article

C2 - 18990065

AN - SCOPUS:56749154067

SN - 1058-4838

VL - 47

SP - 1575

EP - 1578

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

Neutrophils may be a vehicle for viral replication and dissemination in human h5n1 avian influenza

Abstract

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