Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles

C. N. P. Lui; Y. P. Tsui; A. S. L. Ho; D. K. Y. Shum; Y. S. Chan; C. T. Wu; Hung Wing LI; S. C. Edman Tsang; Kin Lam YUNG

doi:10.1002/anie.201305482

Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles

C. N. P. Lui
, Y. P. Tsui
, A. S. L. Ho
, D. K. Y. Shum^*
, Y. S. Chan^*
, C. T. Wu^*
, Hung Wing LI^*
, S. C. Edman Tsang^*
, Kin Lam YUNG^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

20 Citations (Scopus)

Abstract

It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.

Original language	English
Pages (from-to)	12298-12302
Number of pages	5
Journal	Angewandte Chemie. International Edition
Volume	52
Issue number	47
Early online date	24 Sept 2013
DOIs	https://doi.org/10.1002/anie.201305482
Publication status	Published - 18 Nov 2013

User-Defined Keywords

antibodies
magnetic nanoparticles
nanoparticles
regenerative medicine
stem cells

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10.1002/anie.201305482

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abstract = "It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.",

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AU - Lui, C. N. P.

AU - Tsui, Y. P.

AU - Ho, A. S. L.

AU - Shum, D. K. Y.

AU - Chan, Y. S.

AU - Wu, C. T.

AU - LI, Hung Wing

AU - Tsang, S. C. Edman

AU - YUNG, Kin Lam

PY - 2013/11/18

Y1 - 2013/11/18

N2 - It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.

AB - It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.

KW - antibodies

KW - magnetic nanoparticles

KW - nanoparticles

KW - regenerative medicine

KW - stem cells

UR - https://www.scopus.com/pages/publications/84887522188

U2 - 10.1002/anie.201305482

DO - 10.1002/anie.201305482

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AN - SCOPUS:84887522188

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JO - Angewandte Chemie. International Edition

JF - Angewandte Chemie. International Edition

IS - 47

ER -

Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles

Abstract

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