Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles

C. N. P. Lui, Y. P. Tsui, A. S. L. Ho, D. K. Y. Shum*, Y. S. Chan*, C. T. Wu*, Hung Wing LI*, S. C. Edman Tsang*, Kin Lam YUNG*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

19 Citations (Scopus)


It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.

Original languageEnglish
Pages (from-to)12298-12302
Number of pages5
JournalAngewandte Chemie. International Edition
Issue number47
Early online date24 Sept 2013
Publication statusPublished - 18 Nov 2013

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • antibodies
  • magnetic nanoparticles
  • nanoparticles
  • regenerative medicine
  • stem cells


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