Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles

C. N.P. Lui, Y. P. Tsui, A. S.L. Ho, D. K.Y. Shum, Y. S. Chan, C. T. Wu, Hung Wing LI, S. C.Edman Tsang, Kin Lam YUNG

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.

Original languageEnglish
Pages (from-to)12298-12302
Number of pages5
JournalAngewandte Chemie. International Edition
Volume52
Issue number47
DOIs
Publication statusPublished - 18 Nov 2013

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • antibodies
  • magnetic nanoparticles
  • nanoparticles
  • regenerative medicine
  • stem cells

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