Neural correlates of enhanced response inhibition in the aftermath of stress

Jingjing Chang; Jianping Hu; Chiang Shan R. Li; Rongjun Yu

doi:10.1016/j.neuroimage.2019.116212

Neural correlates of enhanced response inhibition in the aftermath of stress

Jingjing Chang, Jianping Hu, Chiang Shan R. Li, Rongjun Yu^*

^*Corresponding author for this work

Department of Management, Marketing and Information Systems

Research output: Contribution to journal › Journal article › peer-review

19 Citations (Scopus)

Abstract

Life stress has been shown to impact cognitive functions, including inhibitory control. However, the immediate effects of acute stress on inhibitory control and the underlying neural mechanisms remain unclear. In a behavioral pilot study (N = 30) and a within-subject functional magnetic resonance imaging study (N = 30), we examined how acute stress induced by Trier Social Stress Test influenced inhibitory control in a stop signal task. Behavioral results across two studies showed that stress consistently improved inhibitory control. Shorter stop signal reaction time (SSRT) in stress as compared with control condition was associated with stronger connectivity between the superior/middle frontal gyrus (SFG/MFG) and striatum. Dynamic causal modeling revealed distinct best models under stress and control condition, with an enhanced interaction between the SFG/MFG and the striatum after stress exposure. This research identified the SFG/MFG-striatum network as a key circuit underlying acute stress-elicited enhancement of inhibitory control in a stop signal task.

Original language	English
Article number	116212
Journal	NeuroImage
Volume	204
DOIs	https://doi.org/10.1016/j.neuroimage.2019.116212
Publication status	Published - 1 Jan 2020

Scopus Subject Areas

Neurology
Cognitive Neuroscience

User-Defined Keywords

Prefrontal cortex
Response inhibition
Stop signal task
Stress
Striatum

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10.1016/j.neuroimage.2019.116212

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title = "Neural correlates of enhanced response inhibition in the aftermath of stress",

abstract = "Life stress has been shown to impact cognitive functions, including inhibitory control. However, the immediate effects of acute stress on inhibitory control and the underlying neural mechanisms remain unclear. In a behavioral pilot study (N = 30) and a within-subject functional magnetic resonance imaging study (N = 30), we examined how acute stress induced by Trier Social Stress Test influenced inhibitory control in a stop signal task. Behavioral results across two studies showed that stress consistently improved inhibitory control. Shorter stop signal reaction time (SSRT) in stress as compared with control condition was associated with stronger connectivity between the superior/middle frontal gyrus (SFG/MFG) and striatum. Dynamic causal modeling revealed distinct best models under stress and control condition, with an enhanced interaction between the SFG/MFG and the striatum after stress exposure. This research identified the SFG/MFG-striatum network as a key circuit underlying acute stress-elicited enhancement of inhibitory control in a stop signal task.",

keywords = "Prefrontal cortex, Response inhibition, Stop signal task, Stress, Striatum",

author = "Jingjing Chang and Jianping Hu and Li, {Chiang Shan R.} and Rongjun Yu",

note = "Funding Information: We acknowledge Natural Scientific Foundation of China (No. 81771186) to RY and NIH grants AA021449, DA023248 and DA044749 to CRL for support of the study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/j.neuroimage.2019.116212",

language = "English",

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T1 - Neural correlates of enhanced response inhibition in the aftermath of stress

AU - Chang, Jingjing

AU - Hu, Jianping

AU - Li, Chiang Shan R.

AU - Yu, Rongjun

N1 - Funding Information: We acknowledge Natural Scientific Foundation of China (No. 81771186) to RY and NIH grants AA021449, DA023248 and DA044749 to CRL for support of the study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2019 Elsevier Inc.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Life stress has been shown to impact cognitive functions, including inhibitory control. However, the immediate effects of acute stress on inhibitory control and the underlying neural mechanisms remain unclear. In a behavioral pilot study (N = 30) and a within-subject functional magnetic resonance imaging study (N = 30), we examined how acute stress induced by Trier Social Stress Test influenced inhibitory control in a stop signal task. Behavioral results across two studies showed that stress consistently improved inhibitory control. Shorter stop signal reaction time (SSRT) in stress as compared with control condition was associated with stronger connectivity between the superior/middle frontal gyrus (SFG/MFG) and striatum. Dynamic causal modeling revealed distinct best models under stress and control condition, with an enhanced interaction between the SFG/MFG and the striatum after stress exposure. This research identified the SFG/MFG-striatum network as a key circuit underlying acute stress-elicited enhancement of inhibitory control in a stop signal task.

AB - Life stress has been shown to impact cognitive functions, including inhibitory control. However, the immediate effects of acute stress on inhibitory control and the underlying neural mechanisms remain unclear. In a behavioral pilot study (N = 30) and a within-subject functional magnetic resonance imaging study (N = 30), we examined how acute stress induced by Trier Social Stress Test influenced inhibitory control in a stop signal task. Behavioral results across two studies showed that stress consistently improved inhibitory control. Shorter stop signal reaction time (SSRT) in stress as compared with control condition was associated with stronger connectivity between the superior/middle frontal gyrus (SFG/MFG) and striatum. Dynamic causal modeling revealed distinct best models under stress and control condition, with an enhanced interaction between the SFG/MFG and the striatum after stress exposure. This research identified the SFG/MFG-striatum network as a key circuit underlying acute stress-elicited enhancement of inhibitory control in a stop signal task.

KW - Prefrontal cortex

KW - Response inhibition

KW - Stop signal task

KW - Stress

KW - Striatum

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DO - 10.1016/j.neuroimage.2019.116212

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AN - SCOPUS:85073055965

SN - 1053-8119

VL - 204

JO - NeuroImage

JF - NeuroImage

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ER -

Neural correlates of enhanced response inhibition in the aftermath of stress

Abstract

Scopus Subject Areas

User-Defined Keywords

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