Neural and retinal characteristics in relation to working memory in older adults with mild cognitive impairment

Mabel N.K. Wong, Daniel W.L. Lai, Henry H.L. Chan, Bess Y.H. Lam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: 

This study investigated the relationship between neural activities and retinal structures associated with working memory (WM) in older adults with mild cognitive impairment (MCI).

Methods: 

Eleven older adults with MCI and 29 healthy controls (60 to 73 years old) were tested. All participants underwent an event-related potential (ERP) recording while performing the two-back memory task. The Optical coherence tomography angiography (OCT-A) was administered to examine the perfusion and vessel density in the retina. 

Results: 

Results showed that WM performance in the MCI group was negatively associated with ERP latencies in central parietal regions (CP6 and CP8) (ps< 0.05). The left nasal vessel and perfusion densities were negatively correlated with the latencies in these two central parietal regions and positively related to WM performance only in the MCI group (ps< 0.05). 

Conclusion: 

The findings on WM, central parietal brain activity, and left nasal vessel and perfusion densities in the retina help us gain a better understanding of the neural and retinal underpinnings of WM in relation to MCI.

Original languageEnglish
Pages (from-to)185-195
Number of pages11
JournalCurrent Alzheimer Research
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 2021

Scopus Subject Areas

  • Neurology
  • Clinical Neurology

User-Defined Keywords

  • Cognition
  • Event-related potential
  • Mild cognitive impairment
  • Retinal perfusion density
  • Retinal vessel density
  • Working memory

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