@article{f2169a3df2c34f629dfa5b7a18d19db6,
title = "Near-Infrared and Visible Dual-Emitting Peptide by Modular Assembly of Nitrobenzoxadiazole and Neodymium Complexes",
abstract = "The synthetic difficulty of target-specific lanthanide complexes, despite their unique characteristics, limits their use in in vitro/ in vivo studies and biomedical applications. With commercially available and affordable reagents, a facile synthetic approach is developed to modularly deploy nitrobenzoxadiazole and neodymium complexes onto bioactive peptides. The yielded probes show observable neodymium emission with specific localization to corresponding biotargets in vitro, which became the first example of a stable, water-soluble, and target-specific neodymium(III) complex applicable for in vitro imaging with detectable brightness.",
keywords = "lanthanide probes, neodymium, NIR probes, nitrobenzoxadiazole, solid-phase peptide synthesis",
author = "Yeung, {Yik Hoi} and Chau, {Ho Fai} and Kai, {Hei Yui} and Wanqi Zhou and Chan, {Kaitlin Hao Yi} and Waygen Thor and Charbonni{\`e}re, {Lo{\"i}c J.} and Fan Zhang and Yong Fan and Yue Wu and Wong, {Ka Leung}",
note = "K.-L.W. gratefully acknowledges the financial assistance from the Hong Kong Research Grants Council Grant No. 12300021, NSFC/RGC Joint Research Scheme (N_PolyU209/21), and the Centre for Medical Engineering of Molecular and Biological Probes (AoE/M-401/20). The precious advice in writing provided by Dr. Wai-Sum Lo from the Department of Applied Biology and Chemical Technology (ABCT) of The Hong Kong Polytechnic University (HKPolyU) is greatly appreciated. The authors also appreciate the service of high-resolution mass spectrometry provided by The University Research Facility in Life Sciences (ULS) of HKPolyU. Publisher Copyright: {\textcopyright} 2024 The Authors.",
year = "2024",
month = mar,
day = "22",
doi = "10.1002/adom.202302070",
language = "English",
volume = "12",
journal = "Advanced Optical Materials",
issn = "2195-1071",
publisher = "John Wiley & Sons Ltd.",
number = "9",
}