@article{3eacc9bbb9fb4bf9bfb1cdc85a32575c,
title = "Natural products reverse cancer multidrug resistance",
abstract = "Cancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor MDR. Discovering novel potential modulators to reduce tumor MDR by Natural Product-Derived Compounds has become a popular research area across the globe. Numerous studies mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their MDR modulatory activity. Natural products reverse MDR by regulating signaling pathways or the relevant expressed protein or gene. Here we perform a deep review of the previous achievements, recent advances in the development of natural products as a treatment for MDR. This review aims to provide some insights for the study of multidrug resistance of natural products.",
keywords = "cancer, MDR, mechanism, multidrug resistance, natural product-derived compounds",
author = "Zou, {Jia Yu} and Chen, {Qi Lei} and Luo, {Xiao Ci} and Davaadagva Damdinjav and Abdelmohsen, {Usama Ramadan} and Li, {Hong Yan} and Tungalag Battulga and Chen, {Hu Biao} and Wang, {Yu Qing} and Jianye Zhang",
note = "The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Fund of Guangdong Science and Technology Department (2022A0505050080), the National Key R&D Program of China (2021YFE0202000), the Fund of Guangzhou Science and Technology Program (202002030410), Innovation and Technology Fund in Hong Kong (MHP/023/20), the Affiliated Qingyuan Hospital of Guangzhou Medical University (202301-301), Ministry of Education Engineering Research Center of Tibetan Medicine Detection Technology (2022-ZYZXK07), Guangzhou Medical University Undergraduates project (pdjh 2022b0425, 02-410-2206301). Publisher Copyright: Copyright {\textcopyright} 2024 Zou, Chen, Luo, Damdinjav, Abdelmohsen, Li, Battulga, Chen, Wang and Zhang.",
year = "2024",
month = mar,
day = "8",
doi = "10.3389/fphar.2024.1348076",
language = "English",
volume = "15",
journal = "Frontiers in Pharmacology",
issn = "1663-9812",
publisher = "Frontiers Media S.A.",
}
