TY - JOUR
T1 - Natural ingredient-based polymeric nanoparticles for cancer treatment
AU - Wong, Ka Hong
AU - Lu , Aiping
AU - Chen, Xiaoyu
AU - Yang, Zhijun
N1 - Funding Information:
This work was supported by the Hong Kong Baptist University Special Development Fund (SDF18-0319-P03) and the Innovation and Technology Commission of the government of Hong Kong (ITS/348/18FX).
Publisher copyright:
© 2020 by the authors.
PY - 2020/8/2
Y1 - 2020/8/2
N2 - Cancer is a global health challenge. There are drawbacks to conventional chemotherapy such as poor bioavailability, development of drug resistance and severe side effects. Novel drug delivery system may be an alternative to optimize therapeutic effects. When such systems consist of natural materials, they offer important advantages: they are usually highly biocompatible, biodegradable, nontoxic and nonimmunogenic. Furthermore, natural materials can be easily modified for conjugation with a wide range of therapeutic agents and targeting ligands, according to the therapeutic purpose. This article reviews different natural ingredients and their applications in drug delivery systems for cancer therapy. Firstly, an overview of the polysaccharides and protein-based polymers that have been extensively investigated for drug delivery are described. Secondly, recent advances in using various natural ingredient-based polymeric nanoparticles for cancer therapy are reviewed. The characteristics of these delivery systems are summarized, followed by a discussion of future development and clinical potential. This review aims to summarize current knowledge and provide a basis for developing effective tailor-made formulations for cancer therapy in the future.
AB - Cancer is a global health challenge. There are drawbacks to conventional chemotherapy such as poor bioavailability, development of drug resistance and severe side effects. Novel drug delivery system may be an alternative to optimize therapeutic effects. When such systems consist of natural materials, they offer important advantages: they are usually highly biocompatible, biodegradable, nontoxic and nonimmunogenic. Furthermore, natural materials can be easily modified for conjugation with a wide range of therapeutic agents and targeting ligands, according to the therapeutic purpose. This article reviews different natural ingredients and their applications in drug delivery systems for cancer therapy. Firstly, an overview of the polysaccharides and protein-based polymers that have been extensively investigated for drug delivery are described. Secondly, recent advances in using various natural ingredient-based polymeric nanoparticles for cancer therapy are reviewed. The characteristics of these delivery systems are summarized, followed by a discussion of future development and clinical potential. This review aims to summarize current knowledge and provide a basis for developing effective tailor-made formulations for cancer therapy in the future.
KW - Cancer therapy
KW - Drug delivery system
KW - Nanoparticles
KW - Natural materials
KW - Polymers
UR - http://www.scopus.com/inward/record.url?scp=85089408307&partnerID=8YFLogxK
U2 - 10.3390/molecules25163620
DO - 10.3390/molecules25163620
M3 - Review article
C2 - 32784890
AN - SCOPUS:85089408307
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 16
M1 - 3620
ER -
