Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea

Hongjie ZHANG, Ghee Teng Tan, Vu Dinh Hoang, Nguyen Van Hung, Nguyen Manh Cuong, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

In a continuing search for anti-HIV compounds from plants of Vietnam, 19 compounds, including a new triterpene, were isolated from an extract of the leaves and stem of Vatica cinerea. The new triterpene was determined to be a cycloartane triterpenoid with 29 skeletal carbons and was assigned the name vaticinone (1). The known triterpenes included three cycloartanes, a lanostane, two dammaranes, three lupanes, an ursane, and an oleanane. A chlorophyll isolate was identified as pheophorbide a (13). The majority of the triterpenes, the sesquiterpene, 1-hydroxycyclocolorenone, and pheophorbide a showed anti-HIV activity, with the chlorophyll being the most active, demonstrating an IC50 value of 1.5 μg/mL (2.5/μM), while being completely devoid of toxicity up to a concentration of 20 μg/mL (33.8 μM). Vaticinone (1) was found to inhibit the replication of HIV-1, with an IC50 value of 6.5 μg/mL (15.3/μM; selective index = 1.4). The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalJournal of Natural Products
Volume66
Issue number2
DOIs
Publication statusPublished - 1 Feb 2003

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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