Abstract
In a continuing search for anti-HIV compounds from plants of Vietnam, 19 compounds, including a new triterpene, were isolated from an extract of the leaves and stem of Vatica cinerea. The new triterpene was determined to be a cycloartane triterpenoid with 29 skeletal carbons and was assigned the name vaticinone (1). The known triterpenes included three cycloartanes, a lanostane, two dammaranes, three lupanes, an ursane, and an oleanane. A chlorophyll isolate was identified as pheophorbide a (13). The majority of the triterpenes, the sesquiterpene, 1-hydroxycyclocolorenone, and pheophorbide a showed anti-HIV activity, with the chlorophyll being the most active, demonstrating an IC50 value of 1.5 μg/mL (2.5/μM), while being completely devoid of toxicity up to a concentration of 20 μg/mL (33.8 μM). Vaticinone (1) was found to inhibit the replication of HIV-1, with an IC50 value of 6.5 μg/mL (15.3/μM; selective index = 1.4). The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra.
Original language | English |
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Pages (from-to) | 263-268 |
Number of pages | 6 |
Journal | Journal of Natural Products |
Volume | 66 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2003 |
Scopus Subject Areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry