Natural anti-HIV agents - Part I: (+)-Demethoxyepiexcelsin and verticillatol from Litsea verticillata

Vu Dinh Hoang, Ghee Teng Tan, Hongjie ZHANG, Pamela A. Tamez, Nguyen Van Hung, Nguyen Manh Cuong, D. Doel Soejarto, Harry H.S. Fong, John M. Pezzuto

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

The eudesmane sesquiterpenoid, verticillatol (1), as well as the lignan, (+)-5′-demethoxyepiexcelsin (2), and a known lignan, (+)-epiexcelsin (3), were isolated from Litsea verticillata Hance. Lignan 2 showed moderate anti-HIV activity with an IC50 value of 16.4 μg/ml (42.7 μM), while the known lignan 3 was inactive up to a concentration of 20 μg/ml (48.3 μM). Compound 1 demonstrated weak activity with an IC50 value of 34.5 μg/ml (144.7 μM) while being devoid of cytotoxicity at 20 μg/ml. The structures were elucidated by ID and 2D NMR spectroscopy, and the absolute configuration of the new sesquiterpenoid was determined by the generation of Mosher esters.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalPhytochemistry
Volume59
Issue number3
DOIs
Publication statusPublished - 20 Feb 2002

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

User-Defined Keywords

  • (+)-5′-Demethoxyepiexcelsin
  • 2D NMR
  • Absolute structure
  • Anti-HIV activity
  • Green fluorescent protein
  • HOG.R5
  • Lauraceae
  • Lignan
  • Litsea verticillata
  • Reporter cell line
  • Sesquiterpene
  • Verticillatol

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