@article{5f0b0c744bd14faba27b2cb06357152a,
title = "Natural anti-HIV agents. Part 3: Litseaverticillols A-H, novel sesquiterpenes from Litsea verticillata",
abstract = "Bioassay directed-fractionation led to the identification of litseaverticillols A-H (1-8) from the leaves and twigs of Litsea verticillata Hance. These new sesquiterpenes possess a unique skeleton that was recently designated as 'litseane'. The structures of these compounds were determined by spectroscopic means including 1D and 2D NMR data. Structural configurations were determined by ROESY experiments. Mosher ester reactions and optical rotation measurements established the sesquiterpenes 1-8 as racemates. Isolates 1-8 inhibited HIV-1 replication in HOG.R5 cells with IC50 values ranging from 2 to 15μg/ml (8-58μM) while affecting the growth of HOG.R5 at concentrations 2-3-fold higher. Based on this data, structure-activity relationships can be discerned, suggesting compounds of this class are good candidates for analog production.",
keywords = "Anti-HIV activity, Bioassay-directed fractionation, Lauraceae, Litsea verticillata, Litseane, Litseaverticillols A-H, Sesquiterpenes",
author = "Hongjie ZHANG and Tan, {Ghee Teng} and Hoang, {Vu Dinh} and Hung, {Nguyen Van} and Cuong, {Nguyen Manh} and Soejarto, {Djaja Doel} and Pezzuto, {John M.} and Fong, {Harry H.S.}",
note = "Funding Information: All work involving plant sample collection, taxonomic identification, bioassay-guided chemical isolation, and structure elucidation in connection with this paper were carried out under a grant administered by the Fogarty International Center, NIH (Grant 1 UO1-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) program. The authors are grateful to the Research Resources Center, University of Illinois at Chicago for access to the Bruker DRX 500 MHz instrument, and to the Center Research Group of the College of Pharmacy, University of Illinois at Chicago for the acquisition of MS data. The authors also wish to acknowledge the AIDS Research and Reference Reagent Program, NIAID, NIH for the supply of reagents critical to this study.",
year = "2003",
month = jan,
day = "6",
doi = "10.1016/S0040-4020(02)01491-6",
language = "English",
volume = "59",
pages = "141--148",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd.",
number = "2",
}
