Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata

Hongjie ZHANG; Ghee Teng Tan; Vu Dinh Hoang; Nguyen Van Hung; Nguyen Manh Cuong; Djaja Doel Soejarto; John M. Pezzuto; Harry H.S. Fong

doi:10.1016/S0040-4039(01)01852-4

Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata

Hongjie ZHANG
, Ghee Teng Tan
, Vu Dinh Hoang
, Nguyen Van Hung
, Nguyen Manh Cuong
, Djaja Doel Soejarto
, John M. Pezzuto
, Harry H.S. Fong

Research output: Contribution to journal › Journal article › peer-review

39 Citations (Scopus)

Abstract

We report herein the first isolation of a novel structural type sesquiterpene designated as 'litseane' from the twigs and leaves of Litsea verticillata Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the replication of human immunodeficiency virus (HIV) type 1 with an IC₅₀ value of 5.0 μg/mL (21.4 μM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given.

Original language	English
Pages (from-to)	8587-8591
Number of pages	5
Journal	Tetrahedron Letters
Volume	42
Issue number	49
DOIs	https://doi.org/10.1016/S0040-4039(01)01852-4
Publication status	Published - 3 Dec 2001

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10.1016/S0040-4039(01)01852-4

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@article{1b154f6c87f1482090f37ec6cd5e483f,

title = "Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata",

abstract = "We report herein the first isolation of a novel structural type sesquiterpene designated as 'litseane' from the twigs and leaves of Litsea verticillata Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the replication of human immunodeficiency virus (HIV) type 1 with an IC50 value of 5.0 μg/mL (21.4 μM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given.",

author = "Hongjie ZHANG and Tan, \{Ghee Teng\} and Hoang, \{Vu Dinh\} and Hung, \{Nguyen Van\} and Cuong, \{Nguyen Manh\} and Soejarto, \{Djaja Doel\} and Pezzuto, \{John M.\} and Fong, \{Harry H.S.\}",

note = "Funding Information: All work involving plant sample collection, taxonomic identification, bioassay-guided chemical isolation, and structure elucidation in connection with this paper were carried out under a grant administered by the Fogarty International Center, NIH (Grant 1 UO1-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) program. The authors are grateful to the Research Resources Center, University of Illinois at Chicago for access to the Bruker DRX 500 MHz instrument, and to the Center Research Group of the College of Pharmacy, University of Illinois at Chicago for the acquisition of MS data. ",

year = "2001",

month = dec,

day = "3",

doi = "10.1016/S0040-4039(01)01852-4",

language = "English",

volume = "42",

pages = "8587--8591",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "49",

}

TY - JOUR

T1 - Natural anti-HIV agents. Part 2

T2 - Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata

AU - ZHANG, Hongjie

AU - Tan, Ghee Teng

AU - Hoang, Vu Dinh

AU - Hung, Nguyen Van

AU - Cuong, Nguyen Manh

AU - Soejarto, Djaja Doel

AU - Pezzuto, John M.

AU - Fong, Harry H.S.

N1 - Funding Information: All work involving plant sample collection, taxonomic identification, bioassay-guided chemical isolation, and structure elucidation in connection with this paper were carried out under a grant administered by the Fogarty International Center, NIH (Grant 1 UO1-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) program. The authors are grateful to the Research Resources Center, University of Illinois at Chicago for access to the Bruker DRX 500 MHz instrument, and to the Center Research Group of the College of Pharmacy, University of Illinois at Chicago for the acquisition of MS data.

PY - 2001/12/3

Y1 - 2001/12/3

N2 - We report herein the first isolation of a novel structural type sesquiterpene designated as 'litseane' from the twigs and leaves of Litsea verticillata Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the replication of human immunodeficiency virus (HIV) type 1 with an IC50 value of 5.0 μg/mL (21.4 μM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given.

AB - We report herein the first isolation of a novel structural type sesquiterpene designated as 'litseane' from the twigs and leaves of Litsea verticillata Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the replication of human immunodeficiency virus (HIV) type 1 with an IC50 value of 5.0 μg/mL (21.4 μM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given.

UR - https://www.scopus.com/pages/publications/0035802989

U2 - 10.1016/S0040-4039(01)01852-4

DO - 10.1016/S0040-4039(01)01852-4

M3 - Journal article

AN - SCOPUS:0035802989

SN - 0040-4039

VL - 42

SP - 8587

EP - 8591

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 49

ER -

Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata

Abstract

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