Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata

Hongjie ZHANG, Ghee Teng Tan, Vu Dinh Hoang, Nguyen Van Hung, Nguyen Manh Cuong, Djaja Doel Soejarto, John M. Pezzuto, Harry H.S. Fong

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

We report herein the first isolation of a novel structural type sesquiterpene designated as 'litseane' from the twigs and leaves of Litsea verticillata Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the replication of human immunodeficiency virus (HIV) type 1 with an IC50 value of 5.0 μg/mL (21.4 μM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given.

Original languageEnglish
Pages (from-to)8587-8591
Number of pages5
JournalTetrahedron Letters
Volume42
Issue number49
DOIs
Publication statusPublished - 3 Dec 2001

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata'. Together they form a unique fingerprint.

Cite this