@article{1b154f6c87f1482090f37ec6cd5e483f,
title = "Natural anti-HIV agents. Part 2: Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata",
abstract = "We report herein the first isolation of a novel structural type sesquiterpene designated as 'litseane' from the twigs and leaves of Litsea verticillata Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the replication of human immunodeficiency virus (HIV) type 1 with an IC50 value of 5.0 μg/mL (21.4 μM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given.",
author = "Hongjie ZHANG and Tan, {Ghee Teng} and Hoang, {Vu Dinh} and Hung, {Nguyen Van} and Cuong, {Nguyen Manh} and Soejarto, {Djaja Doel} and Pezzuto, {John M.} and Fong, {Harry H.S.}",
note = "Funding Information: All work involving plant sample collection, taxonomic identification, bioassay-guided chemical isolation, and structure elucidation in connection with this paper were carried out under a grant administered by the Fogarty International Center, NIH (Grant 1 UO1-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) program. The authors are grateful to the Research Resources Center, University of Illinois at Chicago for access to the Bruker DRX 500 MHz instrument, and to the Center Research Group of the College of Pharmacy, University of Illinois at Chicago for the acquisition of MS data. ",
year = "2001",
month = dec,
day = "3",
doi = "10.1016/S0040-4039(01)01852-4",
language = "English",
volume = "42",
pages = "8587--8591",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "49",
}
