Nanoparticle-DNA-polymer composites for hepatocellular carcinoma cell labeling, sensing, and magnetic resonance imaging

Ken C F LEUNG*, Siu Fung Lee, Chi Hin Wong, Chun Pong Chak, Josie M.Y. Lai, Xiao Ming Zhu, Yi Xiang J. Wang, Kathy W.Y. Sham, Christopher H.K. Cheng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

This paper describes comparative studies and protocols in (1) self-assembling of ultrasmall superparamagnetic iron oxide nanoparticle (NP), circular plasmid DNA, and branched polyethylenimine (PEI) composites; (2) magnetofection; (3) gene delivery, (4) magnetic resonance imaging (MRI), and (5) cytotoxicity of the composites toward hepatocellular carcinoma HepG2 cells.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalMethods
Volume64
Issue number3
DOIs
Publication statusPublished - 15 Dec 2013

Scopus Subject Areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)

User-Defined Keywords

  • Cellular uptake
  • Gene delivery
  • Magnetic resonance imaging
  • Magnetofection
  • Nanoparticle
  • Self-assembly

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