Nanomaterials as assisted matrix of laser desorption/ionization time-of-flight mass spectrometry for the analysis of small molecules

Minghua Lu*, Xueqing Yang, Yixin Yang, Peige Qin, Xiuru Wu, Zongwei CAI

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)

Abstract

Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.

Original languageEnglish
Article number87
JournalNanomaterials
Volume7
Issue number4
DOIs
Publication statusPublished - 21 Apr 2017

Scopus Subject Areas

  • Chemical Engineering(all)
  • Materials Science(all)

User-Defined Keywords

  • Environmental pollutants
  • Laser desorption/ionization
  • Nanomaterial
  • Small biological molecules
  • Time-of-flight mass spectrometry

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