TY - JOUR
T1 - Mutagenicity, genotoxicity and carcinogenic risk assessment of indoor dust from three major cities around the Pearl River Delta
AU - Kang, Yuan
AU - Cheung, Kwai Chung
AU - Wong, Ming H.
N1 - Funding Information:
Financial support from the Research Grants Council of the University Grants Committee of Hong Kong ( HKBU 260209 ) and Special Equipment Grant ( HKBU09 ) and the Mini-AoE (Area of Excellence, RC/AOE/08-09/01 ) Fund from Hong Kong Baptist University are gratefully acknowledged.
PY - 2011/4
Y1 - 2011/4
N2 - The mutagenicity and genotoxicity of workplace dust including commercial office, secondary school, shopping mall, hospital, electronics factory and manufacturing plant in Hong Kong and settled house dust from Hong Kong, Shenzhen and Guangzhou were measured. Results indicated that indoor dust contained both frameshift and base pair substitution mutagens. Dust from manufacturing plant showed highest mutagenic potency on TA98±S9 and TA100±S9 activation, whereas, electronics factory showed highest genotoxicity with and without S9 activation. TA100 (-S9) mutagenic potency was significantly correlated with genotoxicity expressed as SOSIP (-S9) of workplace dust (r2=0.37, p<0.01). The total PAHs concentration of settled house dust from PRD ranged from 1.63 to 29.2μg/g. Linear regression analyses indicated that the PAHs likely accounted for about 45% of the TA98 with S9 mutagenic activity of workplace dust. TA98 (-S9) mutagenicity (r2=0.27, p<0.05) and SOSIP (-S9) of house dust (r2=0.41, p<0.01) were both significantly correlated with the number of inhabitants in the house. To achieve a more accurate cancer risk assessment, the oral bioaccessibility of B(a)A, Chry, B(b+k)F, B(a)P, D(ah)A and I(cd)P in different dust ranging from 1.3% to 17% was taken into account. Risk assessments indicated that about 26% of house dust samples resulted in unacceptable cancer risk (>1×10-6) for preschool children.
AB - The mutagenicity and genotoxicity of workplace dust including commercial office, secondary school, shopping mall, hospital, electronics factory and manufacturing plant in Hong Kong and settled house dust from Hong Kong, Shenzhen and Guangzhou were measured. Results indicated that indoor dust contained both frameshift and base pair substitution mutagens. Dust from manufacturing plant showed highest mutagenic potency on TA98±S9 and TA100±S9 activation, whereas, electronics factory showed highest genotoxicity with and without S9 activation. TA100 (-S9) mutagenic potency was significantly correlated with genotoxicity expressed as SOSIP (-S9) of workplace dust (r2=0.37, p<0.01). The total PAHs concentration of settled house dust from PRD ranged from 1.63 to 29.2μg/g. Linear regression analyses indicated that the PAHs likely accounted for about 45% of the TA98 with S9 mutagenic activity of workplace dust. TA98 (-S9) mutagenicity (r2=0.27, p<0.05) and SOSIP (-S9) of house dust (r2=0.41, p<0.01) were both significantly correlated with the number of inhabitants in the house. To achieve a more accurate cancer risk assessment, the oral bioaccessibility of B(a)A, Chry, B(b+k)F, B(a)P, D(ah)A and I(cd)P in different dust ranging from 1.3% to 17% was taken into account. Risk assessments indicated that about 26% of house dust samples resulted in unacceptable cancer risk (>1×10-6) for preschool children.
KW - Bioaccessibility
KW - Settled house dust
KW - TA100
KW - TA98
UR - http://www.scopus.com/inward/record.url?scp=79951549404&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2011.01.001
DO - 10.1016/j.envint.2011.01.001
M3 - Journal article
AN - SCOPUS:79951549404
SN - 0160-4120
VL - 37
SP - 637
EP - 643
JO - Environment International
JF - Environment International
IS - 3
ER -
