Mutagenicity, genotoxicity and carcinogenic risk assessment of indoor dust from three major cities around the Pearl River Delta

Yuan Kang, Kwai Chung Cheung, Ming Hung WONG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

The mutagenicity and genotoxicity of workplace dust including commercial office, secondary school, shopping mall, hospital, electronics factory and manufacturing plant in Hong Kong and settled house dust from Hong Kong, Shenzhen and Guangzhou were measured. Results indicated that indoor dust contained both frameshift and base pair substitution mutagens. Dust from manufacturing plant showed highest mutagenic potency on TA98±S9 and TA100±S9 activation, whereas, electronics factory showed highest genotoxicity with and without S9 activation. TA100 (-S9) mutagenic potency was significantly correlated with genotoxicity expressed as SOSIP (-S9) of workplace dust (r2=0.37, p<0.01). The total PAHs concentration of settled house dust from PRD ranged from 1.63 to 29.2μg/g. Linear regression analyses indicated that the PAHs likely accounted for about 45% of the TA98 with S9 mutagenic activity of workplace dust. TA98 (-S9) mutagenicity (r2=0.27, p<0.05) and SOSIP (-S9) of house dust (r2=0.41, p<0.01) were both significantly correlated with the number of inhabitants in the house. To achieve a more accurate cancer risk assessment, the oral bioaccessibility of B(a)A, Chry, B(b+k)F, B(a)P, D(ah)A and I(cd)P in different dust ranging from 1.3% to 17% was taken into account. Risk assessments indicated that about 26% of house dust samples resulted in unacceptable cancer risk (>1×10-6) for preschool children.

Original languageEnglish
Pages (from-to)637-643
Number of pages7
JournalEnvironmental International
Volume37
Issue number3
DOIs
Publication statusPublished - Apr 2011

Scopus Subject Areas

  • Environmental Science(all)

User-Defined Keywords

  • Bioaccessibility
  • Settled house dust
  • TA100
  • TA98

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