TY - JOUR
T1 - Mutagenicity and genotoxicity of Hong Kong soils contaminated by polycyclic aromatic hydrocarbons and dioxins/furans
AU - Man, Yu Bon
AU - Chow, Ka Lai
AU - Kang, Yuan
AU - Wong, Ming Hung
N1 - Funding Information:
The authors would like to thank the Public Policy Research (2002-PPR-3) of the Research Grants Council of Hong Kong, Seed Collaborative Research Fund from the State Key Laboratory in Marine Pollution ( SCRF0003 ), and Joint Research Scheme (JRS) of the National Natural Science Foundation of China (NSFC) and the Research Grants Council (RGC) (N_HKBU210/11) of Hong Kong Joint Research Scheme (JRS) for financial support.
PY - 2013/4/15
Y1 - 2013/4/15
N2 - The aim of this study was to evaluate mutagenicity and genotoxicity of soils from 12 different land use types such as electronic waste dismantling workshop, open burning site and car dismantling workshop (CDW), based on soil concentrations of polycyclic aromatic hydrocarbons (PAHs), and polychlorinated dibenzo- p-dioxins/polychlorinated dibenzofurans (PCDD/Fs). Soils of CDW contained the sum of 10 PAHs level (94392 μg/kg) exceeded The New Dutch List (Dutch Intervention Value (40000 μg/kg)), dominated by high molecular PAHs (99.6%) and benzo(a)pyrene (82.6%), indicating its potential carcinogenic risks. In addition, Ames test and SOS Chromotest further manifested that soil of CDW had a significantly higher mutagenic potency (MP) of 13.8 and 7.43 on both strains of TA98 and TA100 with S9 mix, respectively, and a relatively higher genotoxicity with S9 mix (SOS inducing potency = 1.16), amongst the 12 different soil types. BaP TEQ PAHs in soils were significantly correlated with MP of TA98, with and without S9 mix (r= 0.858 and r= 0.976 at p< 0.01); MP of TA100 with and without S9 mix (r= 0.666 at p< 0.05 and r= 0.819 at p< 0.01); and SOSIP of Escherichia coli PQ 37 with S9 mix (r= 0.693 at p< 0.05), accordingly. Soils of CDW possessed a higher carcinogenic risk (mutagenicity and genotoxicity), based on PAHs concentrations. Bioremediation is recommended to treat the contaminated soils.
AB - The aim of this study was to evaluate mutagenicity and genotoxicity of soils from 12 different land use types such as electronic waste dismantling workshop, open burning site and car dismantling workshop (CDW), based on soil concentrations of polycyclic aromatic hydrocarbons (PAHs), and polychlorinated dibenzo- p-dioxins/polychlorinated dibenzofurans (PCDD/Fs). Soils of CDW contained the sum of 10 PAHs level (94392 μg/kg) exceeded The New Dutch List (Dutch Intervention Value (40000 μg/kg)), dominated by high molecular PAHs (99.6%) and benzo(a)pyrene (82.6%), indicating its potential carcinogenic risks. In addition, Ames test and SOS Chromotest further manifested that soil of CDW had a significantly higher mutagenic potency (MP) of 13.8 and 7.43 on both strains of TA98 and TA100 with S9 mix, respectively, and a relatively higher genotoxicity with S9 mix (SOS inducing potency = 1.16), amongst the 12 different soil types. BaP TEQ PAHs in soils were significantly correlated with MP of TA98, with and without S9 mix (r= 0.858 and r= 0.976 at p< 0.01); MP of TA100 with and without S9 mix (r= 0.666 at p< 0.05 and r= 0.819 at p< 0.01); and SOSIP of Escherichia coli PQ 37 with S9 mix (r= 0.693 at p< 0.05), accordingly. Soils of CDW possessed a higher carcinogenic risk (mutagenicity and genotoxicity), based on PAHs concentrations. Bioremediation is recommended to treat the contaminated soils.
KW - Ames test
KW - Genotoxicity
KW - Mutagenicity
KW - PAHs
KW - PCDD/Fs
KW - SOS Chromotest
UR - http://www.scopus.com/inward/record.url?scp=84875407370&partnerID=8YFLogxK
U2 - 10.1016/j.mrgentox.2013.01.004
DO - 10.1016/j.mrgentox.2013.01.004
M3 - Journal article
C2 - 23391780
AN - SCOPUS:84875407370
SN - 1383-5718
VL - 752
SP - 47
EP - 56
JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
IS - 1-2
ER -
