Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci

Bengang Xing; Chun Wing Yu; Pak Leung Ho; Kin Hung Chow; Terence Cheung; Hongwei Gu; Zongwei CAI; Bing Xu

doi:10.1021/jm030417q

Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci

Bengang Xing, Chun Wing Yu, Pak Leung Ho, Kin Hung Chow, Terence Cheung, Hongwei Gu, Zongwei CAI, Bing Xu^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

51 Citations (Scopus)

Abstract

Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H ₂O)₂]²⁺, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.

Original language	English
Pages (from-to)	4904-4909
Number of pages	6
Journal	Journal of Medicinal Chemistry
Volume	46
Issue number	23
DOIs	https://doi.org/10.1021/jm030417q
Publication status	Published - 6 Nov 2003

Scopus Subject Areas

Molecular Medicine
Drug Discovery

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10.1021/jm030417q

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@article{91d421f2ea3e4d96bfed40caf07fabd6,

title = "Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci",

abstract = "Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H 2O)2]2+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.",

author = "Bengang Xing and Yu, {Chun Wing} and Ho, {Pak Leung} and Chow, {Kin Hung} and Terence Cheung and Hongwei Gu and Zongwei CAI and Bing Xu",

note = "This work was partially supported by the Research Grant Council of Hong Kong, DuPont Young Faculty Grant (for Xu), Direct Allocation Grants (HKUST), and University Development Fund (HKU). ",

year = "2003",

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doi = "10.1021/jm030417q",

language = "English",

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T1 - Multivalent Antibiotics via Metal Complexes

T2 - Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci

AU - Xing, Bengang

AU - Yu, Chun Wing

AU - Ho, Pak Leung

AU - Chow, Kin Hung

AU - Cheung, Terence

AU - Gu, Hongwei

AU - CAI, Zongwei

AU - Xu, Bing

N1 - This work was partially supported by the Research Grant Council of Hong Kong, DuPont Young Faculty Grant (for Xu), Direct Allocation Grants (HKUST), and University Development Fund (HKU).

PY - 2003/11/6

Y1 - 2003/11/6

N2 - Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H 2O)2]2+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.

AB - Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H 2O)2]2+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.

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U2 - 10.1021/jm030417q

DO - 10.1021/jm030417q

M3 - Journal article

C2 - 14584941

AN - SCOPUS:0242331083

SN - 0022-2623

VL - 46

SP - 4904

EP - 4909

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 23

ER -

Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci

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