Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci

Bengang Xing, Chun Wing Yu, Pak Leung Ho, Kin Hung Chow, Terence Cheung, Hongwei Gu, Zongwei CAI, Bing Xu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H 2O)2]2+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.

Original languageEnglish
Pages (from-to)4904-4909
Number of pages6
JournalJournal of Medicinal Chemistry
Volume46
Issue number23
DOIs
Publication statusPublished - 6 Nov 2003

Scopus Subject Areas

  • Molecular Medicine
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci'. Together they form a unique fingerprint.

Cite this