Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging

Chen Xie, Yue Wu, Ho-Fai Chau, Tao Zhang*, Carlos Tinlong Wong, Yik-Hoi Yeung, Pak-Lun Lam, Jean-Claude G. Bünzli, Loïc J. Charbonnière*, Ga-Lai Law*, Ka-Leung Wong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights.
Original languageEnglish
Article number2203057
Number of pages7
JournalAdvanced Optical Materials
Volume11
Issue number11
Early online date8 Mar 2023
DOIs
Publication statusPublished - 5 Jun 2023

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

User-Defined Keywords

  • bioorthogonal chemistry
  • lanthanides
  • luminescence
  • magnetic resonance imaging

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