TY - JOUR
T1 - Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging
AU - Xie, Chen
AU - Wu, Yue
AU - Chau, Ho-Fai
AU - Zhang, Tao
AU - Wong, Carlos Tinlong
AU - Yeung, Yik-Hoi
AU - Lam, Pak-Lun
AU - Bünzli, Jean-Claude G.
AU - Charbonnière, Loïc J.
AU - Law, Ga-Lai
AU - Wong, Ka-Leung
N1 - Funding Information:
C.X. and Y.W. contributed equally to this work. G.-L.L. gratefully acknowledges The Hong Kong Polytechnic University ((a) University Research Facility in Chemical and Environmental Analysis (UCEA); (b) University Research Facility in Life Sciences (ULS)) and the Hong Kong Research (grant Nos. 15300919, 15301120, and 153021/18P). K.-L.W. gratefully acknowledges the financial assistance from the Hong Kong Research Grants Council (grant No. 12300021), Dr. Mok Man Hung Endowed Professorship in Chemistry, HKBU–Durham Lanthanide Joint Research Center – Lanthanide Tools for Systems Medicine (grant No. SDF19-1011-P02), and the Centre for Medical Engineering of Molecular and Biological Probes (grant No. AoE/M-401/20).
Publisher copyright:
© 2023 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH
PY - 2023/6/5
Y1 - 2023/6/5
N2 - Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights.
AB - Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights.
KW - bioorthogonal chemistry
KW - lanthanides
KW - luminescence
KW - magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=85150510656&partnerID=8YFLogxK
U2 - 10.1002/adom.202203057
DO - 10.1002/adom.202203057
M3 - Journal article
SN - 2195-1071
VL - 11
JO - Advanced Optical Materials
JF - Advanced Optical Materials
IS - 11
M1 - 2203057
ER -