MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Wenqing Chen; Zhu Zhang; Shiqing Zhang; Peili Zhu; Joshua Ka Shun  Ko; Ken Kin Lam Yung

doi:10.3390/ijms22126567

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Wenqing Chen, Zhu Zhang, Shiqing Zhang, Peili Zhu, Joshua Ka Shun Ko ^*, Ken Kin Lam Yung^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

122 Citations (Scopus)

Abstract

The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.

Original language	English
Article number	6567
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	12
DOIs	https://doi.org/10.3390/ijms22126567
Publication status	Published - 2 Jun 2021

Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

User-Defined Keywords

Epithelial cancer
Immunotherapy
MUC1
MUC1 cell barrier
Therapeutic biomarkers
Tumor oncogene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms22126567

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title = "MUC1: Structure, Function, and Clinic Application in Epithelial Cancers",

abstract = "The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.",

keywords = "Epithelial cancer, Immunotherapy, MUC1, MUC1 cell barrier, Therapeutic biomarkers, Tumor oncogene",

author = "Wenqing Chen and Zhu Zhang and Shiqing Zhang and Peili Zhu and Ko, {Joshua Ka Shun} and Yung, {Ken Kin Lam}",

note = "Funding Information: This work was supported in part by the Department of Science and Technology of Guangdong Province (Grant No. 2021A1515012092). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Chen, Wenqing

AU - Zhang, Zhu

AU - Zhang, Shiqing

AU - Zhu, Peili

AU - Ko , Joshua Ka Shun

AU - Yung, Ken Kin Lam

N1 - Funding Information: This work was supported in part by the Department of Science and Technology of Guangdong Province (Grant No. 2021A1515012092). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6/2

Y1 - 2021/6/2

N2 - The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.

AB - The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.

KW - Epithelial cancer

KW - Immunotherapy

KW - MUC1

KW - MUC1 cell barrier

KW - Therapeutic biomarkers

KW - Tumor oncogene

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SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

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ER -

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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