m5C Methylation Guides Systemic Transport of Messenger RNA over Graft Junctions in Plants

Lei Yang, Valentina Perrera, Eleftheria Saplaoura, Federico Apelt, Mathieu Bahin, Amira Kramdi, Justyna Olas, Bernd Mueller-Roeber, Ewelina Sokolowska, Wenna Zhang, Runsheng LI, Nicolas Pitzalis, Manfred Heinlein, Shoudong ZHANG, Auguste Genovesio, Vincent Colot, Friedrich Kragler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

In plants, thousands of messenger RNAs move to distant body parts to potentially act as systemic signals. Yang, Pererra, et al. show that 5-methylcytosine (m5C) modification of mobile RNA plays a crucial role in facilitating their transport and present evidence that mobile m5C-modified TCTP1 is translated in target cells and changes root growth.

Original languageEnglish
Pages (from-to)2465-2476.e5
JournalCurrent Biology
Volume29
Issue number15
DOIs
Publication statusPublished - 5 Aug 2019

Scopus Subject Areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

User-Defined Keywords

  • grafting
  • long-distance transport
  • mC
  • mRNA methylation
  • mRNA modification
  • mRNA transport
  • phloem
  • plasmodesmata
  • root development

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