TY - JOUR
T1 - Moving the goal posts
T2 - Enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy
AU - Harvey, Peter
AU - Blamire, Andrew M.
AU - Wilson, J. Ian
AU - Finney, Katie Louise N.A.
AU - Funk, Alexander M.
AU - Senanayake, P. Kanthi
AU - Parker, David
N1 - We thank the ERC (FCC 266804), CRUK and EPSRC for support.
Publisher Copyright:
©The Royal Society of Chemistry 2013
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance, the resonance is shifted to a region of the 1H NMR spectral window far away from the usual 0–12 ppm range, permitting selective observation. Furthermore, judicious selection of the lanthanide ion, according to the applied magnetic field strength, leads to relaxation rate enhancements of the order of 100–200, permitting more rapid data acquisition per unit time in both spectroscopy and imaging experiments. The enhanced sensitivity allows the detection of these complexes in mice within a few minutes using shift imaging, following tail vein injection of doses of the order of 0.1 mmol kg−1.
AB - Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance, the resonance is shifted to a region of the 1H NMR spectral window far away from the usual 0–12 ppm range, permitting selective observation. Furthermore, judicious selection of the lanthanide ion, according to the applied magnetic field strength, leads to relaxation rate enhancements of the order of 100–200, permitting more rapid data acquisition per unit time in both spectroscopy and imaging experiments. The enhanced sensitivity allows the detection of these complexes in mice within a few minutes using shift imaging, following tail vein injection of doses of the order of 0.1 mmol kg−1.
UR - https://www.scopus.com/pages/publications/84885035979
UR - https://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc51526e
U2 - 10.1039/c3sc51526e
DO - 10.1039/c3sc51526e
M3 - Journal article
AN - SCOPUS:84885035979
SN - 2041-6520
VL - 4
SP - 4251
EP - 4258
JO - Chemical Science
JF - Chemical Science
IS - 11
ER -
