Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity

Pan Li; Ze Ming Zhang; Tao Li; Yan-Bo Zhang; Stephen Cho Wing Sze; Guo Cai Wang; Yao Lan Li; Wencai Ye

doi:10.1016/j.fitote.2014.07.017

Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity

Pan Li
, Ze Ming Zhang
, Tao Li
, Yan-Bo Zhang
, Stephen Cho Wing Sze^*
, Guo Cai Wang^*
, Yao Lan Li
, Wencai Ye

^*Corresponding author for this work

Golden Meditech Centre for NeuroRegeneration Sciences

Research output: Contribution to journal › Journal article › peer-review

35 Citations (Scopus)

Abstract

An unusual nor-monoterpene with only nine carbons, nor-paeonilactone (1), two new monoterpenes, paeonisuffrone C (2), paeonilactone D (9), and a new monoterpene glucoside, paeonin D (3), along with ten known compounds were isolated from the dried roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and computational data. Compounds 4–14 were evaluated for their anti-proliferative activities against BT 483 human breast cancer cells and OVCA 429 human ovarian cancer cells by MTT assay.

Original language	English
Pages (from-to)	124-129
Number of pages	6
Journal	Fitoterapia
Volume	98
DOIs	https://doi.org/10.1016/j.fitote.2014.07.017
Publication status	Published - Oct 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Paeonia lactiflora
Paeoniaceae
Monoterpene
Anti-proliferative

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10.1016/j.fitote.2014.07.017

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@article{417fa60a7550497594b16b7972588b4b,

title = "Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity",

abstract = "An unusual nor-monoterpene with only nine carbons, nor-paeonilactone (1), two new monoterpenes, paeonisuffrone C (2), paeonilactone D (9), and a new monoterpene glucoside, paeonin D (3), along with ten known compounds were isolated from the dried roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and computational data. Compounds 4–14 were evaluated for their anti-proliferative activities against BT 483 human breast cancer cells and OVCA 429 human ovarian cancer cells by MTT assay.",

keywords = "Paeonia lactiflora, Paeoniaceae, Monoterpene, Anti-proliferative",

author = "Pan Li and Zhang, \{Ze Ming\} and Tao Li and Yan-Bo Zhang and Sze, \{Stephen Cho Wing\} and Wang, \{Guo Cai\} and Li, \{Yao Lan\} and Wencai Ye",

note = "This research was supported by grants from the National Natural Science Foundation (Nos. 81273390 , 81202429 ), the Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China (2013J2200051 ), and The Natural Science Foundation of Guangdong Province (No. S2013020012864 ).",

year = "2014",

month = oct,

doi = "10.1016/j.fitote.2014.07.017",

language = "English",

volume = "98",

pages = "124--129",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity

AU - Li, Pan

AU - Zhang, Ze Ming

AU - Li, Tao

AU - Zhang, Yan-Bo

AU - Sze, Stephen Cho Wing

AU - Wang, Guo Cai

AU - Li, Yao Lan

AU - Ye, Wencai

N1 - This research was supported by grants from the National Natural Science Foundation (Nos. 81273390 , 81202429 ), the Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China (2013J2200051 ), and The Natural Science Foundation of Guangdong Province (No. S2013020012864 ).

PY - 2014/10

Y1 - 2014/10

N2 - An unusual nor-monoterpene with only nine carbons, nor-paeonilactone (1), two new monoterpenes, paeonisuffrone C (2), paeonilactone D (9), and a new monoterpene glucoside, paeonin D (3), along with ten known compounds were isolated from the dried roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and computational data. Compounds 4–14 were evaluated for their anti-proliferative activities against BT 483 human breast cancer cells and OVCA 429 human ovarian cancer cells by MTT assay.

AB - An unusual nor-monoterpene with only nine carbons, nor-paeonilactone (1), two new monoterpenes, paeonisuffrone C (2), paeonilactone D (9), and a new monoterpene glucoside, paeonin D (3), along with ten known compounds were isolated from the dried roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and computational data. Compounds 4–14 were evaluated for their anti-proliferative activities against BT 483 human breast cancer cells and OVCA 429 human ovarian cancer cells by MTT assay.

KW - Paeonia lactiflora

KW - Paeoniaceae

KW - Monoterpene

KW - Anti-proliferative

UR - https://www.scopus.com/pages/publications/84907363650

U2 - 10.1016/j.fitote.2014.07.017

DO - 10.1016/j.fitote.2014.07.017

M3 - Journal article

SN - 0367-326X

VL - 98

SP - 124

EP - 129

JO - Fitoterapia

JF - Fitoterapia

ER -

Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity

Abstract

UN SDGs

User-Defined Keywords

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