Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity

Pan Li, Ze Ming Zhang, Tao Li, Yan-Bo Zhang, Stephen Cho Wing Sze*, Guo Cai Wang*, Yao Lan Li, Wencai Ye

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

An unusual nor-monoterpene with only nine carbons, nor-paeonilactone (1), two new monoterpenes, paeonisuffrone C (2), paeonilactone D (9), and a new monoterpene glucoside, paeonin D (3), along with ten known compounds were isolated from the dried roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and computational data. Compounds 4–14 were evaluated for their anti-proliferative activities against BT 483 human breast cancer cells and OVCA 429 human ovarian cancer cells by MTT assay.
Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalFitoterapia
Volume98
DOIs
Publication statusPublished - Oct 2014

Scopus Subject Areas

  • Medicine(all)

User-Defined Keywords

  • Paeonia lactiflora
  • Paeoniaceae
  • Monoterpene
  • Anti-proliferative

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