Molecular insight into gut microbiota and rheumatoid arthritis

Xiaohao Wu, Bing He, Jin LIU, Hui Feng, Yinghui Ma, Defang LI, Baosheng GUO, Chao LIANG, Lei Dang, Luyao Wang, Jing Tian, Hailong ZHU*, Lianbo Xiao, Cheng Lu, Aiping LYU, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Citations (Scopus)


Rheumatoid arthritis (RA) is a systemic, inflammatory, and autoimmune disorder. Gut microbiota play an important role in the etiology of RA. With the considerable progress made in next-generation sequencing techniques, the identified gut microbiota difference between RA patients and healthy individuals provides an updated overview of the association between gut microbiota and RA. We reviewed the reported correlation and underlying molecular mechanisms among gut microbiota, the immune system, and RA. It has become known that gut microbiota contribute to the pathogenesis of RA via multiple molecular mechanisms. The progressive understanding of the dynamic interaction between gut microbiota and their host will help in establishing a highly individualized management for each RA patient, and achieve a better efficacy in clinical practice, or even discovering new drugs for RA.

Original languageEnglish
Article number431
JournalInternational Journal of Molecular Sciences
Issue number3
Publication statusPublished - 22 Mar 2016

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Gut microbiota
  • Molecular mechanism
  • Rheumatoid arthritis


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