Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

Baosheng GUO, Zong Kang Zhang, Chao LIANG, Jie Li, Jin LIU, Aiping LYU*, Bao Ting Zhang, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)

Abstract

Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.

Original languageEnglish
Pages (from-to)184-192
Number of pages9
JournalCalcified Tissue International
Volume100
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

User-Defined Keywords

  • Bone
  • Myokines
  • Skeletal muscle

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