TY - JOUR
T1 - Molecular Communication from Skeletal Muscle to Bone
T2 - A Review for Muscle-Derived Myokines Regulating Bone Metabolism
AU - Guo, Baosheng
AU - Zhang, Zong Kang
AU - Liang, Chao
AU - Li, Jie
AU - Liu, Jin
AU - Lu, Aiping
AU - Zhang, Bao Ting
AU - Zhang, Ge
N1 - Funding Information:
This work was supported by the Faculty Research Grant of Hong Kong Baptist University (FRG2/13-14/006), the Hong Kong General Research Fund (12136616, 12102914 and 478312), Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University (RC-IRMS/13-14/02 and RC-IRMS/13-14/03), the Research Committee of Hong Kong Baptist University (30-12-286, FRG2/14-15/021 and FRG2/12-13/027), the Science and Technology Innovation Commission of Shenzhen Municipality (SCM-2013-SZTIC-001), Natural Science Foundation Council (81272045, 81401833 and 81572195).
PY - 2017/2
Y1 - 2017/2
N2 - Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.
AB - Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.
KW - Bone
KW - Myokines
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=84994391772&partnerID=8YFLogxK
U2 - 10.1007/s00223-016-0209-4
DO - 10.1007/s00223-016-0209-4
M3 - Review article
C2 - 27830278
AN - SCOPUS:84994391772
SN - 0171-967X
VL - 100
SP - 184
EP - 192
JO - Calcified Tissue International
JF - Calcified Tissue International
IS - 2
ER -
