Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

Baosheng Guo; Zong Kang Zhang; Chao Liang; Jie Li; Jin Liu; Aiping Lu; Bao Ting Zhang; Ge Zhang

doi:10.1007/s00223-016-0209-4

Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

Baosheng Guo, Zong Kang Zhang, Chao Liang, Jie Li, Jin Liu, Aiping Lu^*, Bao Ting Zhang^*, Ge Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.

Original language	English
Pages (from-to)	184-192
Number of pages	9
Journal	Calcified Tissue International
Volume	100
Issue number	2
Early online date	9 Nov 2016
DOIs	https://doi.org/10.1007/s00223-016-0209-4
Publication status	Published - Feb 2017

Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

User-Defined Keywords

Bone
Myokines
Skeletal muscle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00223-016-0209-4

Cite this

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title = "Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism",

abstract = "Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.",

keywords = "Bone, Myokines, Skeletal muscle",

author = "Baosheng Guo and Zhang, {Zong Kang} and Chao Liang and Jie Li and Jin Liu and Aiping Lu and Zhang, {Bao Ting} and Ge Zhang",

note = "Funding Information: This work was supported by the Faculty Research Grant of Hong Kong Baptist University (FRG2/13-14/006), the Hong Kong General Research Fund (12136616, 12102914 and 478312), Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University (RC-IRMS/13-14/02 and RC-IRMS/13-14/03), the Research Committee of Hong Kong Baptist University (30-12-286, FRG2/14-15/021 and FRG2/12-13/027), the Science and Technology Innovation Commission of Shenzhen Municipality (SCM-2013-SZTIC-001), Natural Science Foundation Council (81272045, 81401833 and 81572195).",

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doi = "10.1007/s00223-016-0209-4",

language = "English",

volume = "100",

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journal = "Calcified Tissue International",

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AU - Li, Jie

AU - Liu, Jin

AU - Lu, Aiping

AU - Zhang, Bao Ting

AU - Zhang, Ge

N1 - Funding Information: This work was supported by the Faculty Research Grant of Hong Kong Baptist University (FRG2/13-14/006), the Hong Kong General Research Fund (12136616, 12102914 and 478312), Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University (RC-IRMS/13-14/02 and RC-IRMS/13-14/03), the Research Committee of Hong Kong Baptist University (30-12-286, FRG2/14-15/021 and FRG2/12-13/027), the Science and Technology Innovation Commission of Shenzhen Municipality (SCM-2013-SZTIC-001), Natural Science Foundation Council (81272045, 81401833 and 81572195).

PY - 2017/2

Y1 - 2017/2

N2 - Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.

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Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

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