Modulatory role of 5-HT3 receptors in gastric function and ethanol-induced mucosal damage in rat stomachs

C. H. Cho*, M. W.L. Koo, J. K.S. Ko

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

11 Citations (Scopus)


The involvement of 5-hydroxytryptamine (5-HT) in gastric function and mucosal damage has been defined. 5-HT also potentiates lesion formation in animals. The current study investigated further whether these actions are mediated through 5-HT3 receptors in rats. Ondansetron, a 5-HT3 receptor antagonist, was given subcutaneously, 2 or 4 mg/kg, 30 min before the gastric parameters were measured. The higher dose of ondansetron, 4 mg/kg, significantly increased gastric mucosal blood flow (GMBF) and also basal acid and Na+ secretion. However, it did not affect pepsin output. 5-HT time dependently reduced GMBF and pepsin secretion, but not that of acid and Na+. These actions were not altered by ondansetron pretreatment. The drug, however, dose dependently reduced ethanol-induced gastric mucosal lesions in the 5-HT-treated animals. These findings indicate that 5-HT3 receptors regulate not only basal GMBF, but also acid and Na+ secretion in stomachs. However, the depressive action of 5-HT on GMBF and pepsin secretion is most likely not mediated through 5-HT3receptors. Ondansetron also modulates the toxicities of ethanol in the stomach and this action is likely to be mediated through the preservation of GMBF.

Original languageEnglish
Pages (from-to)137-143
Number of pages8
Issue number3
Publication statusPublished - 1994

Scopus Subject Areas

  • Pharmacology

User-Defined Keywords

  • 5-Hydroxytryptamine
  • Blood flow
  • Ethanol
  • Gastric acid
  • Gastric damage
  • Ondansetron
  • Pepsin
  • Sodium


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