Abstract
The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined. Treatment of influenza A/WSN virus primed primary immune spleen cells and their cultured secondary effector T cells from Balb/c mice with these agonists resulted in increases in cyclic AMP levels. These agents also had a marked inhibitory effect on the cytotoxic activity of primary immune spleen cells, but a much weaker inhibitory effect on that of secondary effector T cells. No significant effect of 8-bromo-cyclic GMP on the cytotoxic activity of these two cell types was observed. The cytotoxic activity of H-2-restricted, virus-specific T cells generated either in vivo (primary) or in vitro (secondary) was not significantly inhibited by treatment with histamine, whereas that alloreactive killer T cells generated in vivo was markedly inhibited. These results suggest that the actions of H-2-restricted, virus-specific T cells may not be regulated by histamine during viral or inflammatory processes.
Original language | English |
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Pages (from-to) | 37-45 |
Number of pages | 9 |
Journal | Immunopharmacology |
Volume | 13 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 1987 |
Scopus Subject Areas
- Pharmacology
User-Defined Keywords
- Cyclic AMP
- Cytotoxic lymphocytes
- Histamine
- Prostaglandin E