Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication)

S S K  Durairajan; M  Li; S K  Chung; Q B  Han; A  Iyaswamy; S G   Sreenivasmurthy; S  Malampati; A K  Kammala

Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication)

S S K Durairajan^*, M Li, S K Chung, Q B Han, A Iyaswamy, S G Sreenivasmurthy, S Malampati, A K Kammala

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

2 Citations (Scopus)

Abstract

1. Huang-Lian-Jie-Du-Tang (HLJDT) is composed of Rhizoma coptidis, Radix scutellariae, Cortex phellodendri, and Fructus gardenia at the ratio of 3:2:2:3. It is a famous traditional Chinese medicine. We found that HLJDT increased the amyloid-β (Aβ) load in an Alzheimer disease mouse model owing to the APP-increasing effect of baicalein, which is the main pure compound of a constituent herb, Radix scutellariae.

2. In contrast, the modified HLJDT is composed of Rhizoma coptidis, Cortex phellodendri, and Fructus gardenia in the ratio of 4:2:4, and showed both memory-enhancing effect and Aβ-reducing effects in an Alzheimer disease mouse model.

3. Upon confirming the modified HLJDT's efficacy and safety profile in clinical trials, the modified HLJDT may be prescribed for treating Alzheimer disease.

Original language	English
Pages (from-to)	S33-S36
Number of pages	4
Journal	Hong Kong Medical Journal
Volume	26
Issue number	6, Suppl 7
Publication status	Published - Dec 2020

Scopus Subject Areas

Medicine(all)

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https://www.hkmj.org/system/files/hkmj2012sp7p33.pdf

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Durairajan, S. S. K., Li, M., Chung, S. K., Han, Q. B., Iyaswamy, A., Sreenivasmurthy, S. G., Malampati, S., & Kammala, A. K. (2020). Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication). Hong Kong Medical Journal, 26(6, Suppl 7), S33-S36. https://www.hkmj.org/system/files/hkmj2012sp7p33.pdf

@article{6f203d2bb1944a69bf0e8cf92b35b936,

title = "Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication)",

abstract = "1. Huang-Lian-Jie-Du-Tang (HLJDT) is composed of Rhizoma coptidis, Radix scutellariae, Cortex phellodendri, and Fructus gardenia at the ratio of 3:2:2:3. It is a famous traditional Chinese medicine. We found that HLJDT increased the amyloid-β (Aβ) load in an Alzheimer disease mouse model owing to the APP-increasing effect of baicalein, which is the main pure compound of a constituent herb, Radix scutellariae.2. In contrast, the modified HLJDT is composed of Rhizoma coptidis, Cortex phellodendri, and Fructus gardenia in the ratio of 4:2:4, and showed both memory-enhancing effect and Aβ-reducing effects in an Alzheimer disease mouse model.3. Upon confirming the modified HLJDT's efficacy and safety profile in clinical trials, the modified HLJDT may be prescribed for treating Alzheimer disease.",

author = "Durairajan, {S S K} and M Li and Chung, {S K} and Han, {Q B} and A Iyaswamy and Sreenivasmurthy, {S G} and S Malampati and Kammala, {A K}",

note = "Funding information: This study was supported by the Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government (#11122511). The full report is available from the Health and Medical Research Fund website (https://rfs1.fhb.gov.hk/index.html). Publisher copyright: {\textcopyright} 2020 Administering Institution and Hong Kong SAR Government",

year = "2020",

month = dec,

language = "English",

volume = "26",

pages = "S33--S36",

journal = "Hong Kong Medical Journal",

issn = "1024-2708",

publisher = "Hong Kong Academy of Medicine Press",

number = "6, Suppl 7",

}

Durairajan, SSK, Li, M, Chung, SK, Han, QB , Iyaswamy, A, Sreenivasmurthy, SG, Malampati, S & Kammala, AK 2020, 'Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication)', Hong Kong Medical Journal, vol. 26, no. 6, Suppl 7, pp. S33-S36. <https://www.hkmj.org/system/files/hkmj2012sp7p33.pdf>

TY - JOUR

T1 - Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease

T2 - an in vivo study (abridged secondary publication)

AU - Durairajan, S S K

AU - Li, M

AU - Chung, S K

AU - Han, Q B

AU - Iyaswamy, A

AU - Sreenivasmurthy, S G

AU - Malampati, S

AU - Kammala, A K

N1 - Funding information: This study was supported by the Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government (#11122511). The full report is available from the Health and Medical Research Fund website (https://rfs1.fhb.gov.hk/index.html). Publisher copyright: © 2020 Administering Institution and Hong Kong SAR Government

PY - 2020/12

Y1 - 2020/12

N2 - 1. Huang-Lian-Jie-Du-Tang (HLJDT) is composed of Rhizoma coptidis, Radix scutellariae, Cortex phellodendri, and Fructus gardenia at the ratio of 3:2:2:3. It is a famous traditional Chinese medicine. We found that HLJDT increased the amyloid-β (Aβ) load in an Alzheimer disease mouse model owing to the APP-increasing effect of baicalein, which is the main pure compound of a constituent herb, Radix scutellariae.2. In contrast, the modified HLJDT is composed of Rhizoma coptidis, Cortex phellodendri, and Fructus gardenia in the ratio of 4:2:4, and showed both memory-enhancing effect and Aβ-reducing effects in an Alzheimer disease mouse model.3. Upon confirming the modified HLJDT's efficacy and safety profile in clinical trials, the modified HLJDT may be prescribed for treating Alzheimer disease.

AB - 1. Huang-Lian-Jie-Du-Tang (HLJDT) is composed of Rhizoma coptidis, Radix scutellariae, Cortex phellodendri, and Fructus gardenia at the ratio of 3:2:2:3. It is a famous traditional Chinese medicine. We found that HLJDT increased the amyloid-β (Aβ) load in an Alzheimer disease mouse model owing to the APP-increasing effect of baicalein, which is the main pure compound of a constituent herb, Radix scutellariae.2. In contrast, the modified HLJDT is composed of Rhizoma coptidis, Cortex phellodendri, and Fructus gardenia in the ratio of 4:2:4, and showed both memory-enhancing effect and Aβ-reducing effects in an Alzheimer disease mouse model.3. Upon confirming the modified HLJDT's efficacy and safety profile in clinical trials, the modified HLJDT may be prescribed for treating Alzheimer disease.

UR - https://www.hkmj.org/abstracts/v26%20Suppl%207n6/33.htm

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M3 - Journal article

C2 - 33229617

AN - SCOPUS:85096732411

SN - 1024-2708

VL - 26

SP - S33-S36

JO - Hong Kong Medical Journal

JF - Hong Kong Medical Journal

IS - 6, Suppl 7

ER -

Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication)

Abstract

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