Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication)

S S K Durairajan*, M Li, S K Chung, Q B Han, A Iyaswamy, S G Sreenivasmurthy, S Malampati, A K Kammala

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. Huang-Lian-Jie-Du-Tang (HLJDT) is composed of Rhizoma coptidis, Radix scutellariae, Cortex phellodendri, and Fructus gardenia at the ratio of 3:2:2:3. It is a famous traditional Chinese medicine. We found that HLJDT increased the amyloid-β (Aβ) load in an Alzheimer disease mouse model owing to the APP-increasing effect of baicalein, which is the main pure compound of a constituent herb, Radix scutellariae.

2. In contrast, the modified HLJDT is composed of Rhizoma coptidis, Cortex phellodendri, and Fructus gardenia in the ratio of 4:2:4, and showed both memory-enhancing effect and Aβ-reducing effects in an Alzheimer disease mouse model.

3. Upon confirming the modified HLJDT's efficacy and safety profile in clinical trials, the modified HLJDT may be prescribed for treating Alzheimer disease.
Original languageEnglish
Pages (from-to)S33-S36
Number of pages4
JournalHong Kong Medical Journal
Volume26
Issue number6, Suppl 7
Publication statusPublished - Dec 2020

Scopus Subject Areas

  • Medicine(all)

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