TY - JOUR
T1 - Mixed Treatments Comparison of Oral Nutrition Interventions for Blood Immune Cell Parameters in Cancer Patients
T2 - Systematic Review and Network Meta-Analysis
AU - Fang, Yufei
AU - Xu, Yining
AU - Zhang, Yuting
AU - Ren, Feng
AU - Baker, Julien S.
N1 - This study was supported by the Zhejiang Province Medical and Health Science and Technology Plan Project (No. 2018KY710), the Ningbo Public Welfare Science and Technology Plan Project (No. 2019C50095), the Health Youth Technical Talent Cultivation Special Fund Project (2020SWSQNGG-01), the Ningbo Medical Science and Technology Plan (2020Y14), the Young Cultivation Fund Project of The Affiliated of School of Medicine of Ningbo University (FYQM-KY-202003), the Open Fund Project of Institute of Human Biomechanics of Ningbo University (CJ-HBIO202112), and the K.C. Wong Magna Fund in Ningbo University.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/9/15
Y1 - 2022/9/15
N2 - Oral nutrition interventions are commonly applied as an assistant therapeutic approach, which could affect the balance of the immunological response but with mixed evidence. The objective of this study is to identify the potential of different oral nutrition interventions for blood immune cell parameters in cancer patients. Randomized controlled trials, which were published in peer-reviewed journals in the language of English, and which identified the effects of different oral nutrition interventions on cancer patients, were screened and included in the databases of PubMed, Medline, Embase, and Web of Science. White blood cell count (WBC), lymphocyte count, CD4/CD8, and neutrophil count were selected as outcome measures. For the result, 11 trials were included. The agreement between authors reached a kappa value of 0.78. Beta-carotene supplementation has a high potential in inducing a positive effect on blood immune cell parameters for cancer patients (first positive for WBC and CD4/CD8, second positive for lymphocyte count), as well as a combination of physical exercise and hypocaloric healthy eating intervention (first positive for lymphocyte and neutrophil count, second positive for WBC). Oral nutrition supplementations with a single substance have less potential to provide a positive effect on blood immune cell parameters for cancer patients (glutamine: 0.30 and 0.28 to be the last selection for WBCs and lymphocytes; Omega 3: 0.37 to be the last selection for WBCs; Protein: 0.44 to be the last selection for lymphocytes; Zinc: 0.60 to be the last selection for neutrophils). In conclusion, the programs of immunonutrition therapy for different cancer patients might be different. The past perception that mixed oral nutritional supplementations are superior to oral nutritional supplements with a single substance might be wrong and the selection of oral nutritional supplementation need cautiousness. A combination of physical exercise might have a positive effect but also needs a higher level of evidence.
AB - Oral nutrition interventions are commonly applied as an assistant therapeutic approach, which could affect the balance of the immunological response but with mixed evidence. The objective of this study is to identify the potential of different oral nutrition interventions for blood immune cell parameters in cancer patients. Randomized controlled trials, which were published in peer-reviewed journals in the language of English, and which identified the effects of different oral nutrition interventions on cancer patients, were screened and included in the databases of PubMed, Medline, Embase, and Web of Science. White blood cell count (WBC), lymphocyte count, CD4/CD8, and neutrophil count were selected as outcome measures. For the result, 11 trials were included. The agreement between authors reached a kappa value of 0.78. Beta-carotene supplementation has a high potential in inducing a positive effect on blood immune cell parameters for cancer patients (first positive for WBC and CD4/CD8, second positive for lymphocyte count), as well as a combination of physical exercise and hypocaloric healthy eating intervention (first positive for lymphocyte and neutrophil count, second positive for WBC). Oral nutrition supplementations with a single substance have less potential to provide a positive effect on blood immune cell parameters for cancer patients (glutamine: 0.30 and 0.28 to be the last selection for WBCs and lymphocytes; Omega 3: 0.37 to be the last selection for WBCs; Protein: 0.44 to be the last selection for lymphocytes; Zinc: 0.60 to be the last selection for neutrophils). In conclusion, the programs of immunonutrition therapy for different cancer patients might be different. The past perception that mixed oral nutritional supplementations are superior to oral nutritional supplements with a single substance might be wrong and the selection of oral nutritional supplementation need cautiousness. A combination of physical exercise might have a positive effect but also needs a higher level of evidence.
KW - nutrition
KW - supplementation
KW - immune
KW - systematic review
KW - network meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85138612149&partnerID=8YFLogxK
U2 - 10.3390/metabo12090868
DO - 10.3390/metabo12090868
M3 - Journal article
AN - SCOPUS:85138612149
SN - 2218-1989
VL - 12
JO - Metabolites
JF - Metabolites
IS - 9
M1 - 868
ER -