Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers

Miu Shan Chan; Dick Yan Tam; Ziwen Dai; Ling Sum Liu; Jonathan Weng Thim Ho; Man Lee Chan; Di Xu; Man Shing Wong; Chung Tin; Pik Kwan Lo

doi:10.1002/smll.201503051

Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers

Miu Shan Chan
, Dick Yan Tam
, Ziwen Dai
, Ling Sum Liu
, Jonathan Weng Thim Ho
, Man Lee Chan
, Di Xu
, Man Shing Wong
, Chung Tin^*
, Pik Kwan Lo

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

37 Citations (Scopus)

Abstract

The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers. Delivery of the anticancer drug doxorubicin to mitochondria by lipid-functionalized DNA nanocages (LNCs) is demonstrated for the first time. The results suggest outstanding potential for the use of LNCs as drug nanocarriers in treatments for organelle-specific diseases.

Original language	English
Pages (from-to)	770-781
Number of pages	12
Journal	Small
Volume	12
Issue number	6
DOIs	https://doi.org/10.1002/smll.201503051
Publication status	Published - 10 Feb 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

anticancer drugs
delivery
DNA nanocarriers
lipophilic molecules
mitochondria

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10.1002/smll.201503051

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title = "Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers",

abstract = "The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers. Delivery of the anticancer drug doxorubicin to mitochondria by lipid-functionalized DNA nanocages (LNCs) is demonstrated for the first time. The results suggest outstanding potential for the use of LNCs as drug nanocarriers in treatments for organelle-specific diseases.",

keywords = "anticancer drugs, delivery, DNA nanocarriers, lipophilic molecules, mitochondria",

author = "Chan, \{Miu Shan\} and Tam, \{Dick Yan\} and Ziwen Dai and Liu, \{Ling Sum\} and Ho, \{Jonathan Weng Thim\} and Chan, \{Man Lee\} and Di Xu and Wong, \{Man Shing\} and Chung Tin and Lo, \{Pik Kwan\}",

note = "Funding Information: Supporting Information is available from the Wiley Online Library or from the author. This work was supported by National Science Foundation of China 21324077 and 21574109, Hong Kong Research Grants Council (ECS) (CityU 21300314 and 138613) and TDG (CityU TDG 6000495). Funding Information: This work was supported by National Science Foundation of China 21324077 and 21574109, Hong Kong Research Grants Council (ECS) (CityU 21300314 and 138613) and TDG (CityU TDG 6000495).",

year = "2016",

month = feb,

day = "10",

doi = "10.1002/smll.201503051",

language = "English",

volume = "12",

pages = "770--781",

journal = "Small",

issn = "1613-6810",

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TY - JOUR

T1 - Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers

AU - Chan, Miu Shan

AU - Tam, Dick Yan

AU - Dai, Ziwen

AU - Liu, Ling Sum

AU - Ho, Jonathan Weng Thim

AU - Chan, Man Lee

AU - Xu, Di

AU - Wong, Man Shing

AU - Tin, Chung

AU - Lo, Pik Kwan

N1 - Funding Information: Supporting Information is available from the Wiley Online Library or from the author. This work was supported by National Science Foundation of China 21324077 and 21574109, Hong Kong Research Grants Council (ECS) (CityU 21300314 and 138613) and TDG (CityU TDG 6000495). Funding Information: This work was supported by National Science Foundation of China 21324077 and 21574109, Hong Kong Research Grants Council (ECS) (CityU 21300314 and 138613) and TDG (CityU TDG 6000495).

PY - 2016/2/10

Y1 - 2016/2/10

N2 - The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers. Delivery of the anticancer drug doxorubicin to mitochondria by lipid-functionalized DNA nanocages (LNCs) is demonstrated for the first time. The results suggest outstanding potential for the use of LNCs as drug nanocarriers in treatments for organelle-specific diseases.

AB - The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers. Delivery of the anticancer drug doxorubicin to mitochondria by lipid-functionalized DNA nanocages (LNCs) is demonstrated for the first time. The results suggest outstanding potential for the use of LNCs as drug nanocarriers in treatments for organelle-specific diseases.

KW - anticancer drugs

KW - delivery

KW - DNA nanocarriers

KW - lipophilic molecules

KW - mitochondria

UR - https://www.scopus.com/pages/publications/84958741033

U2 - 10.1002/smll.201503051

DO - 10.1002/smll.201503051

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C2 - 26690974

AN - SCOPUS:84958741033

SN - 1613-6810

VL - 12

SP - 770

EP - 781

JO - Small

JF - Small

IS - 6

ER -

Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers

Abstract

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