Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers

Miu Shan Chan, Dick Yan Tam, Ziwen Dai, Ling Sum Liu, Jonathan Weng Thim Ho, Man Lee Chan, Di Xu, Ricky M S WONG, Chung Tin*, Pik Kwan Lo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers. Delivery of the anticancer drug doxorubicin to mitochondria by lipid-functionalized DNA nanocages (LNCs) is demonstrated for the first time. The results suggest outstanding potential for the use of LNCs as drug nanocarriers in treatments for organelle-specific diseases.

Original languageEnglish
Pages (from-to)770-781
Number of pages12
JournalSmall
Volume12
Issue number6
DOIs
Publication statusPublished - 10 Feb 2016

Scopus Subject Areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

User-Defined Keywords

  • anticancer drugs
  • delivery
  • DNA nanocarriers
  • lipophilic molecules
  • mitochondria

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