Microwave-assisted synthesis of BSA-stabilized and HSA-protected gold nanoclusters with red emission

Lei Yan, Yuqing Cai, Baozhan Zheng, Hongyan Yuan, Yong Guo, Dan Xiao*, Martin M F CHOI

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

152 Citations (Scopus)


A microwave (MW)-assisted synthesis method for preparation of fluorescent BSA-stabilized and HSA-protected gold nanoclusters (BSA-AuNCs and HSA-AuNCs) has been developed. The reaction time can be shortened from tens of hours to several minutes, thanks to the superheating and non-thermal effects of the MW energy. The optimal experimental conditions including concentrations of BSA, HAuCl 4 and NaOH and the MW programme are investigated in detail. The as-synthesised BSA-AuNC product is well characterized by UV-vis spectroscopy, fluorescence spectroscopy, HRTEM, XPS, and IR spectroscopy. The HSA-AuNCs display strong red emission which is efficiently quenched by nitrogen oxides (NO x), demonstrating its great potential in determining the intracellular concentration of NO x. The proposed MW-assisted synthesis method is simple, fast and should be applicable to prepare various protein- or enzyme-protected metal nanoclusters.

Original languageEnglish
Pages (from-to)1000-1005
Number of pages6
JournalJournal of Materials Chemistry
Issue number3
Publication statusPublished - 21 Jan 2012

Scopus Subject Areas

  • Chemistry(all)
  • Materials Chemistry


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