This paper describes the first efficient one-step synthesis of 2-aroylbenzofuran-3-ols from the microwave-assisted Dieckmann reaction of substituted methylsalicylates with 2-bromo-1-aroylethanones in alkaline aprotic solvents. This method features excellent yields, short reaction time (15 min) and high functional group compatibility, making it an efficient and practical approach for the synthesis of 2-aroylbenzofuran-3-ols.
Scopus Subject Areas
- Organic Chemistry
- 2-aroylbenzofuran-3-ols; cyclization; Dieckmann reaction; microwave irradiation