microRNA-Mediated Regulation of Bone Remodeling: A Brief Review

Jin LIU; Lei Dang; Xiaohao Wu; Dijie Li; Qing Ren; Aiping LYU; Ge Zhang

doi:10.1002/jbm4.10213

microRNA-Mediated Regulation of Bone Remodeling: A Brief Review

Jin LIU, Lei Dang, Xiaohao Wu, Dijie Li, Qing Ren, Aiping LYU, Ge Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

microRNA (miRNA)-mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating bone remodeling by affecting different stages of osteoblastogenesis, osteocytic differentiation, and osteoclastogenesis to govern osteoblastic bone formation and osteoclastic bone resorption. Moreover, miRNAs are recently implicated in mediating the cell-cell communications among bone cells. This review concentrates on the miRNA-mediated regulatory mechanisms of osteoblasts, osteoclasts, and osteocytes, and their contribution to bone remodeling.

Original language	English
Article number	e10213
Journal	JBMR Plus
Volume	3
Issue number	9
DOIs	https://doi.org/10.1002/jbm4.10213
Publication status	Published - 1 Sep 2019

Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine

User-Defined Keywords

BONE MODELING AND REMODELING
MICRO RNA
OSTEOBLASTS
OSTEOCLASTS
OSTEOCYTES

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10.1002/jbm4.10213

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title = "microRNA-Mediated Regulation of Bone Remodeling: A Brief Review",

abstract = "microRNA (miRNA)-mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating bone remodeling by affecting different stages of osteoblastogenesis, osteocytic differentiation, and osteoclastogenesis to govern osteoblastic bone formation and osteoclastic bone resorption. Moreover, miRNAs are recently implicated in mediating the cell-cell communications among bone cells. This review concentrates on the miRNA-mediated regulatory mechanisms of osteoblasts, osteoclasts, and osteocytes, and their contribution to bone remodeling.",

keywords = "BONE MODELING AND REMODELING, MICRO RNA, OSTEOBLASTS, OSTEOCLASTS, OSTEOCYTES",

author = "Jin LIU and Lei Dang and Xiaohao Wu and Dijie Li and Qing Ren and Aiping LYU and Ge Zhang",

note = "Funding Information: This work was supported by the Hong Kong General Research Fund (HKBU12102914 to GZ; HKBU12101117 to GZ; and HKBU12136616 to JL); the Natural Science Foundation Council of China (81702189 to JL); and the Interdisciplinary Research Clusters Matching Scheme of Hong Kong Baptist University (RC-IRCs/17-18/02 to GZ). Authors? roles: JL and GZ designed the review and wrote most of the manuscript; LD prepared the table and figure and screened the literatures; XHW, DJL and QR did literature searching. APL provided scientific suggestions.",

year = "2019",

month = sep,

day = "1",

doi = "10.1002/jbm4.10213",

language = "English",

volume = "3",

journal = "JBMR Plus",

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T1 - microRNA-Mediated Regulation of Bone Remodeling

T2 - A Brief Review

AU - LIU, Jin

AU - Dang, Lei

AU - Wu, Xiaohao

AU - Li, Dijie

AU - Ren, Qing

AU - LYU, Aiping

AU - Zhang, Ge

N1 - Funding Information: This work was supported by the Hong Kong General Research Fund (HKBU12102914 to GZ; HKBU12101117 to GZ; and HKBU12136616 to JL); the Natural Science Foundation Council of China (81702189 to JL); and the Interdisciplinary Research Clusters Matching Scheme of Hong Kong Baptist University (RC-IRCs/17-18/02 to GZ). Authors? roles: JL and GZ designed the review and wrote most of the manuscript; LD prepared the table and figure and screened the literatures; XHW, DJL and QR did literature searching. APL provided scientific suggestions.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - microRNA (miRNA)-mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating bone remodeling by affecting different stages of osteoblastogenesis, osteocytic differentiation, and osteoclastogenesis to govern osteoblastic bone formation and osteoclastic bone resorption. Moreover, miRNAs are recently implicated in mediating the cell-cell communications among bone cells. This review concentrates on the miRNA-mediated regulatory mechanisms of osteoblasts, osteoclasts, and osteocytes, and their contribution to bone remodeling.

AB - microRNA (miRNA)-mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating bone remodeling by affecting different stages of osteoblastogenesis, osteocytic differentiation, and osteoclastogenesis to govern osteoblastic bone formation and osteoclastic bone resorption. Moreover, miRNAs are recently implicated in mediating the cell-cell communications among bone cells. This review concentrates on the miRNA-mediated regulatory mechanisms of osteoblasts, osteoclasts, and osteocytes, and their contribution to bone remodeling.

KW - BONE MODELING AND REMODELING

KW - MICRO RNA

KW - OSTEOBLASTS

KW - OSTEOCLASTS

KW - OSTEOCYTES

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U2 - 10.1002/jbm4.10213

DO - 10.1002/jbm4.10213

M3 - Review article

AN - SCOPUS:85088375858

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JO - JBMR Plus

JF - JBMR Plus

SN - 2473-4039

IS - 9

M1 - e10213

ER -

microRNA-Mediated Regulation of Bone Remodeling: A Brief Review

Abstract

Scopus Subject Areas

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