microRNA-Mediated Regulation of Bone Remodeling: A Brief Review

Jin LIU, Lei Dang, Xiaohao Wu, Dijie Li, Qing Ren, Aiping LYU, Ge Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

microRNA (miRNA)-mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating bone remodeling by affecting different stages of osteoblastogenesis, osteocytic differentiation, and osteoclastogenesis to govern osteoblastic bone formation and osteoclastic bone resorption. Moreover, miRNAs are recently implicated in mediating the cell-cell communications among bone cells. This review concentrates on the miRNA-mediated regulatory mechanisms of osteoblasts, osteoclasts, and osteocytes, and their contribution to bone remodeling.

Original languageEnglish
Article numbere10213
JournalJBMR Plus
Volume3
Issue number9
DOIs
Publication statusPublished - 1 Sep 2019

Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

User-Defined Keywords

  • BONE MODELING AND REMODELING
  • MICRO RNA
  • OSTEOBLASTS
  • OSTEOCLASTS
  • OSTEOCYTES

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