Microfluidic technologies for vasculature biomimicry

Chong Hu, Yangfan Chen, Ming Jun Andrew Tan, Kangning REN*, Hongkai Wu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Microfluidic technology has been extensively employed in biology and medicine since the field emerged in the 1990s. By utilizing microfluidic approaches, a variety of vascular system-related structures and functions have been mimicked on in vitro platforms. Herein, we begin by introducing microfluidic circulatory devices for the study of two-dimensional (2D) endothelial cells culture. Next, we focus on recent progress on on-chip mimicry of native vasculature, specifically generation of complex three-dimensional (3D) structures within cell-laden hydrogels using microfluidics and self-assembly-based methods. The utilization of microfluidic technology will facilitate the construction of progressively biomimetic in vitro models that have great potential in complementing existing animal models. We envision such platforms to be utilized in a wide range of applications involving vascular systems, including microphysiological studies, drug screening, and disease modeling.

Original languageEnglish
Pages (from-to)4461-4471
Number of pages11
JournalThe Analyst
Volume144
Issue number15
DOIs
Publication statusPublished - 7 Aug 2019

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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