Microbial Metabolomics: From Methods to Translational Applications

Rui Guo, Xialin Luo, Xu Xin, Lian Liu, Xijun Wang, Haitao Lu*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

2 Citations (Scopus)


Most microbe-associated infectious diseases severely affect human health. However, clinical diagnosis of pathogenic diseases remains challenging due to the lack of specific and highly reliable methods. To better understand the diagnosis, pathogenesis, and treatment of these diseases, systems biology-driven metabolomics goes beyond the annotated phenotype and better targets the functions than conventional approaches. As a novel strategy for analysis of metabolomes in microbes, microbial metabolomics has been recently used to study many diseases, such as obesity, urinary tract infection (UTI), and hepatitis C. In this chapter, we attempt to introduce various microbial metabolomics methods to better interpret the microbial metabolism underlying a diversity of infectious diseases and inspire scientists to pay more attention to microbial metabolomics, enabling broadly and efficiently its translational applications to infectious diseases, from molecular diagnosis to therapeutic discovery.
Original languageEnglish
Title of host publicationCancer Metabolomics
Subtitle of host publicationMethods and Applications
EditorsShen Hu
PublisherSpringer Cham
Number of pages17
ISBN (Electronic)9783030516529
ISBN (Print)9783030516512
Publication statusPublished - 1 Apr 2021

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer New York
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

User-Defined Keywords

  • Mass spectrometry
  • Microbial metabolomics
  • Method development
  • Translational applications
  • Infectious diseases


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