TY - CHAP
T1 - Microbial Metabolomics
T2 - From Methods to Translational Applications
AU - Guo, Rui
AU - Luo, Xialin
AU - Xin, Xu
AU - Liu, Lian
AU - Wang, Xijun
AU - Lu, Haitao
N1 - Funding information:
This work was supported by the National Key R&D Program of China (No. 2017YFC1308600 and 2017YFC1308605), the National Natural Science Foundation of China Grants (No. 81274175 and 31670031), the Startup Funding for Specialized Professorship Provided by Shanghai Jiao Tong University (No. WF220441502), and the Fundamental Research Funds for the Central Universities (grant no. 106112015CDJZR468808).
Publisher copyright:
© 2021 Springer Nature Switzerland AG
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Most microbe-associated infectious diseases severely affect human health. However, clinical diagnosis of pathogenic diseases remains challenging due to the lack of specific and highly reliable methods. To better understand the diagnosis, pathogenesis, and treatment of these diseases, systems biology-driven metabolomics goes beyond the annotated phenotype and better targets the functions than conventional approaches. As a novel strategy for analysis of metabolomes in microbes, microbial metabolomics has been recently used to study many diseases, such as obesity, urinary tract infection (UTI), and hepatitis C. In this chapter, we attempt to introduce various microbial metabolomics methods to better interpret the microbial metabolism underlying a diversity of infectious diseases and inspire scientists to pay more attention to microbial metabolomics, enabling broadly and efficiently its translational applications to infectious diseases, from molecular diagnosis to therapeutic discovery.
AB - Most microbe-associated infectious diseases severely affect human health. However, clinical diagnosis of pathogenic diseases remains challenging due to the lack of specific and highly reliable methods. To better understand the diagnosis, pathogenesis, and treatment of these diseases, systems biology-driven metabolomics goes beyond the annotated phenotype and better targets the functions than conventional approaches. As a novel strategy for analysis of metabolomes in microbes, microbial metabolomics has been recently used to study many diseases, such as obesity, urinary tract infection (UTI), and hepatitis C. In this chapter, we attempt to introduce various microbial metabolomics methods to better interpret the microbial metabolism underlying a diversity of infectious diseases and inspire scientists to pay more attention to microbial metabolomics, enabling broadly and efficiently its translational applications to infectious diseases, from molecular diagnosis to therapeutic discovery.
KW - Mass spectrometry
KW - Microbial metabolomics
KW - Method development
KW - Translational applications
KW - Infectious diseases
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103616213&doi=10.1007%2f978-3-030-51652-9_7&partnerID=40&md5=7ba61c11a9ec26a43505aaacb86e9164
U2 - 10.1007/978-3-030-51652-9_7
DO - 10.1007/978-3-030-51652-9_7
M3 - Chapter
SN - 9783030516512
T3 - Advances in Experimental Medicine and Biology
SP - 97
EP - 113
BT - Cancer Metabolomics
A2 - Hu, Shen
PB - Springer Cham
ER -
