TY - JOUR
T1 - Microangiopathy is associated with bone loss in female type 2 diabetes mellitus patients
AU - Zhong, Ni
AU - Zhang, Youyang
AU - Pu, Xiangling
AU - Xu, Bei
AU - Xu, Mingxin
AU - Cai, Haidong
AU - Zhang, Ge
AU - Cui, Ran
AU - Sheng, Hui
AU - Qu, Shen
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (NSFC 81500650), the Fund for Distinguished Young Scholars in Tongji University (2015KJ053), the Shanghai Municipal Natural Science Foundation (13ZR1432100) and the National High Technology Research and Development Programme 863 (2013AA032203).
Publisher copyright:
© The Author(s) 2018
PY - 2018/9/1
Y1 - 2018/9/1
N2 - ObjectiveType 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. MethodsA total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg). Bone mineral density of the lumbar spine, hip and femoral neck was evaluated by dual-energy X-ray absorptiometry. Fundus oculi photography for diabetic retinopathy and 24-h urine protein for diabetic nephropathy were used as markers of microangiopathy in type 2 diabetes mellitus. Characteristics of the patients and bone mineral density were compared. Multivariate analysis was used to study the association between bone mineral density and microangiopathy. Statistical analysis was performed using SPSS 20.0. p < 0.05 was considered statistically significant. ResultsGroup III had the lowest bone mineral density level in both genders. Multivariate analysis revealed that microangiopathy was negatively correlated with bone mineral density in females (lumbar: r = –0.522, p < 0.001; hip: r = –0.301, p = 0.010; femoral neck: r = –0.314, p = 0.009), but not in males, after adjustment for age, body mass index, hypertension, hyperlipidemia, diabetic status, hepatic function, kidney function, sex hormones and 25(OH) vitamin D. ConclusionThese results demonstrate an independent negative correlation between microangiopathy and bone mineral density in postmenopausal female type 2 diabetes mellitus patients.
AB - ObjectiveType 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. MethodsA total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg). Bone mineral density of the lumbar spine, hip and femoral neck was evaluated by dual-energy X-ray absorptiometry. Fundus oculi photography for diabetic retinopathy and 24-h urine protein for diabetic nephropathy were used as markers of microangiopathy in type 2 diabetes mellitus. Characteristics of the patients and bone mineral density were compared. Multivariate analysis was used to study the association between bone mineral density and microangiopathy. Statistical analysis was performed using SPSS 20.0. p < 0.05 was considered statistically significant. ResultsGroup III had the lowest bone mineral density level in both genders. Multivariate analysis revealed that microangiopathy was negatively correlated with bone mineral density in females (lumbar: r = –0.522, p < 0.001; hip: r = –0.301, p = 0.010; femoral neck: r = –0.314, p = 0.009), but not in males, after adjustment for age, body mass index, hypertension, hyperlipidemia, diabetic status, hepatic function, kidney function, sex hormones and 25(OH) vitamin D. ConclusionThese results demonstrate an independent negative correlation between microangiopathy and bone mineral density in postmenopausal female type 2 diabetes mellitus patients.
KW - 24-h urine protein
KW - bone mineral density
KW - microangiopathy
KW - type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85048879964&partnerID=8YFLogxK
U2 - 10.1177/1479164118779386
DO - 10.1177/1479164118779386
M3 - Journal article
C2 - 29893142
AN - SCOPUS:85048879964
SN - 1479-1641
VL - 15
SP - 433
EP - 441
JO - Diabetes and Vascular Disease Research
JF - Diabetes and Vascular Disease Research
IS - 5
ER -
