Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Guanghui Wang; Haifeng Chen; Minghui Huang; Naili Wang; Jinchao Zhang; Yaou Zhang; Ganrong Bai; David W F FONG; Mengsu Yang; Xinsheng Yao

doi:10.1016/j.canlet.2005.10.050

Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Guanghui Wang
, Haifeng Chen
, Minghui Huang
, Naili Wang
, Jinchao Zhang
, Yaou Zhang
, Ganrong Bai
, David W F FONG
, Mengsu Yang^*
, Xinsheng Yao

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

85 Citations (Scopus)

Abstract

Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.

Original language	English
Pages (from-to)	102-109
Number of pages	8
Journal	Cancer Letters
Volume	241
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2005.10.050
Publication status	Published - 8 Sept 2006

User-Defined Keywords

Apoptosis
Methyl protodioscin

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10.1016/j.canlet.2005.10.050

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@article{11c8257e10a84177880e1b089928dfee,

title = "Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells",

abstract = "Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.",

keywords = "Apoptosis, Methyl protodioscin",

author = "Guanghui Wang and Haifeng Chen and Minghui Huang and Naili Wang and Jinchao Zhang and Yaou Zhang and Ganrong Bai and FONG, \{David W F\} and Mengsu Yang and Xinsheng Yao",

note = "Funding Information: This work is supported by the Area of Excellence Scheme (Institute of Molecular Technology for Drug Discovery and Synthesis) established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), and a grant from the National Hi-Tech 863 Program of the Ministry of Science and Technology of China (2003AA2Z2052).",

year = "2006",

month = sep,

day = "8",

doi = "10.1016/j.canlet.2005.10.050",

language = "English",

volume = "241",

pages = "102--109",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

AU - Wang, Guanghui

AU - Chen, Haifeng

AU - Huang, Minghui

AU - Wang, Naili

AU - Zhang, Jinchao

AU - Zhang, Yaou

AU - Bai, Ganrong

AU - FONG, David W F

AU - Yang, Mengsu

AU - Yao, Xinsheng

N1 - Funding Information: This work is supported by the Area of Excellence Scheme (Institute of Molecular Technology for Drug Discovery and Synthesis) established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), and a grant from the National Hi-Tech 863 Program of the Ministry of Science and Technology of China (2003AA2Z2052).

PY - 2006/9/8

Y1 - 2006/9/8

N2 - Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.

AB - Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.

KW - Apoptosis

KW - Methyl protodioscin

UR - https://www.scopus.com/pages/publications/34247631739

U2 - 10.1016/j.canlet.2005.10.050

DO - 10.1016/j.canlet.2005.10.050

M3 - Journal article

C2 - 16458429

AN - SCOPUS:34247631739

SN - 0304-3835

VL - 241

SP - 102

EP - 109

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Abstract

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