Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Guanghui Wang, Haifeng Chen, Minghui Huang, Naili Wang, Jinchao Zhang, Yaou Zhang, Ganrong Bai, David W F FONG, Mengsu Yang*, Xinsheng Yao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.

Original languageEnglish
Pages (from-to)102-109
Number of pages8
JournalCancer Letters
Volume241
Issue number1
DOIs
Publication statusPublished - 8 Sep 2006

Scopus Subject Areas

  • Oncology
  • Cancer Research

User-Defined Keywords

  • Apoptosis
  • Methyl protodioscin

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