Methods to design and synthesize antibody-drug conjugates (ADCs)

Houzong Yao, Feng Jiang, Aiping Lyu, Ge Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)
59 Downloads (Pure)


Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.

Original languageEnglish
Article number194
JournalInternational Journal of Molecular Sciences
Issue number2
Publication statusPublished - 2 Feb 2016

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Antibody-drug conjugates (ADCs)
  • Drugs
  • Linkers
  • Monoclonal antibodies (mAbs)
  • Targeted therapy


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