TY - JOUR
T1 - Methods to design and synthesize antibody-drug conjugates (ADCs)
AU - Yao, Houzong
AU - Jiang, Feng
AU - Lyu, Aiping
AU - Zhang, Ge
PY - 2016/2/2
Y1 - 2016/2/2
N2 - Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.
AB - Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.
KW - Antibody-drug conjugates (ADCs)
KW - Drugs
KW - Linkers
KW - Monoclonal antibodies (mAbs)
KW - Targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=84956912894&partnerID=8YFLogxK
U2 - 10.3390/ijms17020194
DO - 10.3390/ijms17020194
M3 - Review article
C2 - 26848651
AN - SCOPUS:84956912894
SN - 1661-6596
VL - 17
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 2
M1 - 194
ER -
