Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity

Sze Wing Ng, Lai Hon Chung, Chi Fung Yeung, Hoi Shing Lo, Hau Lam Shek, Tian Shu Kang, Chung Hang Leung, Edmond Dik Lung MA, Chun Yuen Wong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The two families of RuII-chromene and -chromone complexes isolated in this work represent the first examples of metalated chromene and chromone complexes synthesized through transition-metal-mediated cyclization of phenol-tethered ynone. These unprecedented metalated heterocyclic compounds exhibit remarkable features, such as pH-switchable metal–carbon bonding interactions, photo-triggerable release of organic chromone upon visible-light irradiation, and superior antioxidative property to their organic analogue (1,4-benzopyrone). These findings not only offer mechanistic insights into metal-induced activation of functionalized alkynes, but also add a new dimension to rational design of antioxidants and photo-responsive drug delivery systems.

Original languageEnglish
Pages (from-to)1779-1783
Number of pages5
JournalChemistry - A European Journal
Volume24
Issue number8
DOIs
Publication statusPublished - 6 Feb 2018

Scopus Subject Areas

  • Catalysis
  • Organic Chemistry

User-Defined Keywords

  • alkynes
  • antioxidants
  • chromones
  • photochemistry
  • ruthenium

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