Metal-free access to 3-allyl-2-alkoxychromanonesviaphosphine-catalyzed alkoxy allylation of chromones with MBH carbonates and alcohols

Ling Meng, Xiaoyong Chang, Zhenyang Lin*, Jun WANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A metal-free access to 3-allyl-2-alkoxychromanones by PPh3-catalyzed alkoxy allylation of chromones with MBH carbonates and alcohols is described. This reaction is performed under mild conditions and it shows good functional group tolerance, providing a series of functionalized chromanones in moderate to high yields with excellent diastereoselectivities. Deuterium-labeling experiments to probe a possible mechanism and scale-up reaction were also conducted.

Original languageEnglish
Pages (from-to)2663-2667
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume19
Issue number12
DOIs
Publication statusPublished - 28 Mar 2021

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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