Metal complexes for the detection of disease-related protein biomarkers

Dik Lung Ma; Modi Wang; Chenfu Liu; Xiangmin Miao; Tian Shu Kang; Chung Hang Leung

doi:10.1016/j.ccr.2016.07.010

Metal complexes for the detection of disease-related protein biomarkers

Dik Lung Ma^*
, Modi Wang
, Chenfu Liu
, Xiangmin Miao
, Tian Shu Kang
, Chung Hang Leung

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

55 Citations (Scopus)

Abstract

The detection of pathological biomarkers can allow for the early diagnosis and treatment of human disease, lowering morbidity and improving quality of life. Transition metal complexes have recently found use as luminescent probes for the detection of protein biomarkers. In this review, we highlight recent examples of metal complexes that have been used in DNA-based sensing platforms or as chemosensors for protein biomarkers.

Original language	English
Pages (from-to)	90-105
Number of pages	16
Journal	Coordination Chemistry Reviews
Volume	324
DOIs	https://doi.org/10.1016/j.ccr.2016.07.010
Publication status	Published - 1 Oct 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Metal complexes
Protein biomarkers

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10.1016/j.ccr.2016.07.010

Cite this

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title = "Metal complexes for the detection of disease-related protein biomarkers",

abstract = "The detection of pathological biomarkers can allow for the early diagnosis and treatment of human disease, lowering morbidity and improving quality of life. Transition metal complexes have recently found use as luminescent probes for the detection of protein biomarkers. In this review, we highlight recent examples of metal complexes that have been used in DNA-based sensing platforms or as chemosensors for protein biomarkers.",

keywords = "Metal complexes, Protein biomarkers",

author = "Ma, \{Dik Lung\} and Modi Wang and Chenfu Liu and Xiangmin Miao and Kang, \{Tian Shu\} and Leung, \{Chung Hang\}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004 and FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), National Natural Science Foundation of China ( 21575121 ), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), the Science and Technology Development Fund, Macau SAR (098/2014/A2), the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM MRG044/LCH/2015/ICMS).",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.ccr.2016.07.010",

language = "English",

volume = "324",

pages = "90--105",

journal = "Coordination Chemistry Reviews",

issn = "0010-8545",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Metal complexes for the detection of disease-related protein biomarkers

AU - Ma, Dik Lung

AU - Wang, Modi

AU - Liu, Chenfu

AU - Miao, Xiangmin

AU - Kang, Tian Shu

AU - Leung, Chung Hang

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004 and FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), National Natural Science Foundation of China ( 21575121 ), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), the Science and Technology Development Fund, Macau SAR (098/2014/A2), the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM MRG044/LCH/2015/ICMS).

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The detection of pathological biomarkers can allow for the early diagnosis and treatment of human disease, lowering morbidity and improving quality of life. Transition metal complexes have recently found use as luminescent probes for the detection of protein biomarkers. In this review, we highlight recent examples of metal complexes that have been used in DNA-based sensing platforms or as chemosensors for protein biomarkers.

AB - The detection of pathological biomarkers can allow for the early diagnosis and treatment of human disease, lowering morbidity and improving quality of life. Transition metal complexes have recently found use as luminescent probes for the detection of protein biomarkers. In this review, we highlight recent examples of metal complexes that have been used in DNA-based sensing platforms or as chemosensors for protein biomarkers.

KW - Metal complexes

KW - Protein biomarkers

UR - https://www.scopus.com/pages/publications/84979889705

U2 - 10.1016/j.ccr.2016.07.010

DO - 10.1016/j.ccr.2016.07.010

M3 - Review article

AN - SCOPUS:84979889705

SN - 0010-8545

VL - 324

SP - 90

EP - 105

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

ER -

Metal complexes for the detection of disease-related protein biomarkers

Abstract

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