Metal complexes as potential modulators of inflammatory and autoimmune responses

Chung Hang Leung*, Sheng Lin, Hai Jing Zhong, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

Over the past few decades, the realm of inorganic medicinal chemistry has been dominated by the study of the anti-cancer properties of transition metal complexes, particularly those based on platinum or ruthenium. However, comparatively less attention has been focused on the development of metal complexes for the treatment of inflammatory or autoimmune diseases. Metal complexes possess a number of advantages that render them as attractive alternatives to organic small molecules for the development of therapeutic agents. In this perspective, we highlight recent examples in the development of transition metal complexes as modulators of inflammatory and autoimmune responses. The studies presented here serve to highlight the potential of transition metal complexes in modulating inflammatory or immune pathways in cells.

Original languageEnglish
Pages (from-to)871-884
Number of pages14
JournalChemical Science
Volume6
Issue number2
DOIs
Publication statusPublished - 1 Feb 2015

Scopus Subject Areas

  • Chemistry(all)

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