TY - JOUR
T1 - Metabotropic glutamate receptors
T2 - Potential drug targets
AU - Knöpfel, Thomas
AU - Gasparini, Fabrizio
N1 - Publisher copyright:
© 1996 Published by Elsevier Ltd.
PY - 1996/3
Y1 - 1996/3
N2 - The neurotransmitter glutamate activates not only ionotropic receptors, which mediate fast excitatory synaptic transmission, but also metabotropic receptors. The latter form a large, heterogeneous family of G protein-coupled receptors with specific functions in normal as well as in pathological situations. The diverse cellular responses mediated by metabotropic glutamate receptors and their distinct expression patterns in different brain systems render these receptors potential drug targets with a variety of possible mechanisms of action.
AB - The neurotransmitter glutamate activates not only ionotropic receptors, which mediate fast excitatory synaptic transmission, but also metabotropic receptors. The latter form a large, heterogeneous family of G protein-coupled receptors with specific functions in normal as well as in pathological situations. The diverse cellular responses mediated by metabotropic glutamate receptors and their distinct expression patterns in different brain systems render these receptors potential drug targets with a variety of possible mechanisms of action.
UR - http://www.scopus.com/inward/record.url?scp=0000682752&partnerID=8YFLogxK
U2 - 10.1016/1359-6446(96)89038-6
DO - 10.1016/1359-6446(96)89038-6
M3 - Journal article
AN - SCOPUS:0000682752
SN - 1359-6446
VL - 1
SP - 103
EP - 108
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 3
ER -
