Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang

Hui Sun; Haitao Lv; Aihua Zhang; Xijun Wang

doi:10.1016/B978-0-12-803117-9.00019-6

Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang

Hui Sun^*, Haitao Lv, Aihua Zhang, Xijun Wang

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

Abstract

Alcohol-induced liver damage and the intervention effect of Yinchenhao Tang (YCHT) were characterizing by a metabolomics approach. Urinary samples were analyzed by ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-QTOF-MS) in positive ionization mode. Total ion chromatograms (TIC) obtained from the control, alcohol, and YCHT treated rats were readily distinguishable using a multivariate statistical analysis method. The greatest difference in metabolic profiling was observed from the alcohol treated rats, when compared to the control, and the YCHT treated rats. The ceramide (d18:1/25:0), provides further support for an involvement of the sphingomyelin signaling pathway in alcohol liver damage, and the intervention effects of YCHT.

Original language	English
Title of host publication	Chinmedomics
Subtitle of host publication	The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine
Editors	Xijun Wang, Aihua Zhang, Hui Sun
Publisher	Academic Press
Chapter	19
Pages	293-304
Number of pages	12
ISBN (Electronic)	9780128031186
ISBN (Print)	9780128031179
DOIs	https://doi.org/10.1016/B978-0-12-803117-9.00019-6
Publication status	Published - 17 Jul 2015

User-Defined Keywords

Yinchenhao Tang
alcohol
liver damage
metabolic profiling
biomarkers

Access to Document

10.1016/B978-0-12-803117-9.00019-6

Cite this

Sun, H., Lv, H., Zhang, A., & Wang, X. (2015). Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang. In X. Wang, A. Zhang, & H. Sun (Eds.), Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine (pp. 293-304). Academic Press. https://doi.org/10.1016/B978-0-12-803117-9.00019-6

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Sun, H, Lv, H, Zhang, A & Wang, X 2015, Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang. in X Wang, A Zhang & H Sun (eds), Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine. Academic Press, pp. 293-304. https://doi.org/10.1016/B978-0-12-803117-9.00019-6

Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang. / Sun, Hui; Lv, Haitao; Zhang, Aihua et al.
Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine. ed. / Xijun Wang; Aihua Zhang; Hui Sun. Academic Press, 2015. p. 293-304.

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang

AU - Sun, Hui

AU - Lv, Haitao

AU - Zhang, Aihua

AU - Wang, Xijun

PY - 2015/7/17

Y1 - 2015/7/17

N2 - Alcohol-induced liver damage and the intervention effect of Yinchenhao Tang (YCHT) were characterizing by a metabolomics approach. Urinary samples were analyzed by ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-QTOF-MS) in positive ionization mode. Total ion chromatograms (TIC) obtained from the control, alcohol, and YCHT treated rats were readily distinguishable using a multivariate statistical analysis method. The greatest difference in metabolic profiling was observed from the alcohol treated rats, when compared to the control, and the YCHT treated rats. The ceramide (d18:1/25:0), provides further support for an involvement of the sphingomyelin signaling pathway in alcohol liver damage, and the intervention effects of YCHT.

AB - Alcohol-induced liver damage and the intervention effect of Yinchenhao Tang (YCHT) were characterizing by a metabolomics approach. Urinary samples were analyzed by ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-QTOF-MS) in positive ionization mode. Total ion chromatograms (TIC) obtained from the control, alcohol, and YCHT treated rats were readily distinguishable using a multivariate statistical analysis method. The greatest difference in metabolic profiling was observed from the alcohol treated rats, when compared to the control, and the YCHT treated rats. The ceramide (d18:1/25:0), provides further support for an involvement of the sphingomyelin signaling pathway in alcohol liver damage, and the intervention effects of YCHT.

KW - Yinchenhao Tang

KW - alcohol

KW - liver damage

KW - metabolic profiling

KW - biomarkers

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SN - 9780128031179

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Sun H, Lv H, Zhang A, Wang X. Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang. In Wang X, Zhang A, Sun H, editors, Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine. Academic Press. 2015. p. 293-304 doi: 10.1016/B978-0-12-803117-9.00019-6

Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang

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