Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang

Hui Sun*, Haitao Lv, Aihua Zhang, Xijun Wang

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

Abstract

Alcohol-induced liver damage and the intervention effect of Yinchenhao Tang (YCHT) were characterizing by a metabolomics approach. Urinary samples were analyzed by ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-QTOF-MS) in positive ionization mode. Total ion chromatograms (TIC) obtained from the control, alcohol, and YCHT treated rats were readily distinguishable using a multivariate statistical analysis method. The greatest difference in metabolic profiling was observed from the alcohol treated rats, when compared to the control, and the YCHT treated rats. The ceramide (d18:1/25:0), provides further support for an involvement of the sphingomyelin signaling pathway in alcohol liver damage, and the intervention effects of YCHT.

Original languageEnglish
Title of host publicationChinmedomics
Subtitle of host publicationThe Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine
EditorsXijun Wang, Aihua Zhang, Hui Sun
PublisherAcademic Press
Chapter19
Pages293-304
Number of pages12
ISBN (Electronic)9780128031186
ISBN (Print)9780128031179
DOIs
Publication statusPublished - 17 Jul 2015

Scopus Subject Areas

  • Medicine(all)

User-Defined Keywords

  • Yinchenhao Tang
  • alcohol
  • liver damage
  • metabolic profiling
  • biomarkers

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