Memory rescue and learning in synaptic impaired neuronal circuits

Kwan Tung Li, Daoyun Ji, Changsong Zhou*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)


Neuronal impairment is a characteristic of Alzheimer's disease (AD), but its effect on neural activity dynamics underlying memory deficits is unclear. Here, we studied the effects of synaptic impairment on neural activities associated with memory recall, memory rescue, and learning a new memory, in an integrate-and-fire neuronal network. Our results showed that reducing connectivity decreases the neuronal synchronization of memory neurons and impairs memory recall performance. Although, slow-gamma stimulation rescued memory recall and slow-gamma oscillations, the rescue caused a side effect of activating mixed memories. During the learning of a new memory, reducing connectivity caused impairment in storing the new memory, but did not affect previously stored memories. We also explored the effects of other types of impairments including neuronal loss and excitation-inhibition imbalance and the rescue by general increase of excitability. Our results reveal potential computational mechanisms underlying the memory deficits caused by impairment in AD.

Original languageEnglish
Article number106931
Number of pages21
Issue number7
Early online date29 May 2023
Publication statusPublished - 21 Jul 2023

Scopus Subject Areas

  • General

User-Defined Keywords

  • Cognitive neuroscience
  • Molecular neuroscience
  • Neuroscience


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